# Animal Core

> **NIH NIH P01** · JOHNS HOPKINS UNIVERSITY · 2021 · $391,395

## Abstract

Using the SIVmac251-rhesus macaque model of HIV-1 infection, the Animal Core will
provide the long-term ART-suppressed SIV/macaque platform for all projects of this
proposal. The Animal Core will 1) coordinate all macaque studies across all research
projects, and 2) facilitate acquisition and distribution of valuable animal cells and tissue
samples among all research teams in the Program Project. This Core will provide the in
vivo validation platform and the blood, CSF, and tissue samples and primary cells
necessary to achieve the Program Project’s goals through the following Specific Aims:
Aim 1. To coordinate and perform all macaque studies to include animal acquisition and
MHC screening, SIV inoculation, ART drug administration, longitudinal sampling of blood
(for plasma, serum and PBMCs) and CSF, and biopsy sampling of peripheral lymph
nodes.
Aim 2. To perform comprehensive necropsies to harvest macaque tissues and fluids at
study end points and to perform complete pathology evaluation for all animals.
Aim 3. To administer anti-rhesus CD4 antibody to deplete the latent resting CD4+ T cell
reservoir in SIV-infected ART treated macaques and monitor for evidence of
opportunistic infections.

## Key facts

- **NIH application ID:** 10174706
- **Project number:** 5P01AI131306-05
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** JOSEPH L MANKOWSKI
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $391,395
- **Award type:** 5
- **Project period:** 2017-06-23 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10174706

## Citation

> US National Institutes of Health, RePORTER application 10174706, Animal Core (5P01AI131306-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10174706. Licensed CC0.

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