Abstract The Massachusetts State Public Health Laboratory (MASPHL) is requesting funding from PAR- 20-105 Laboratory Flexible Funding Model (LFFM) (U19) in order to maintain and enhance its testing capability across the Microbiology, Chemistry, and Radiochemistry disciplines. The MASPHL is committed to completing surveillance testing of human and animal food products and enhancing capacity for food defense. MASPHL is accredited to the ISO 17025 standard for nine methods at this time and has many more methods under an ISO-like quality management system umbrella. The Massachusetts Department of Public Health (MADPH) radiochemistry section will work in year one to establish protocols and enhance their quality management system to meet the ISO 17025 standard. In years 2-5, a radiochemistry sampling plan will be established and maintained. By maintaining the laboratory’s rigorous quality standards, both laboratory management and the FDA can be assured of the quality of the results generated at the MASPHL. Over the next five years, the MASPHL is committed to completing all required routine surveillance of manufactured food samples, animal food samples, and food defense assignments. All results will be reported to the ORA-LFFM within the expected timeframe outlined in the cooperative agreement guidance. The lab will successfully complete annual proficiency tests for all methods, and will attend all conference calls, webinars, and will participate in method validations and surveillance assignments as requested. A minimum of two people will attend the annual face to face meeting. Two laboratory analysts will attend the annual GenomeTrakr meeting.