# Qualitative and Quantitative Determination of Pesticides in Beverages and Similar Food Matrices by High Performance Liquid Chromatography-Quadrupole Time-of-Flight (HPLC-QToF) Analysis

> **NIH FDA U19** · NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS · 2020 · $74,695

## Abstract

Application Title: New Jersey Food Testing Program - Food Safety and Defense (2020-2025) 
Project Title: Qualitative and Quantitative Determination of Pesticides in Fruit- and Vegetable-based Beverages 
 by High Performance Liquid Chromatography-Quadrupole Time-of-Flight (HPLC-QToF) Analysis 
Project Summary – Discipline D: Special Projects, Analytical Track 3: Method Development and Validation 
The New Jersey Department of Health (NJDOH) is pursuing the U.S. Food and Drug Administration’s (FDA) 
Laboratory Flexible Funding Model cooperative agreement focused on improving the capability and capacity of 
NJ to maintain food safety and security. Chemical Terrorism, Biomonitoring, Medicinal Marijuana, and Food 
Testing Laboratory (CT Laboratory) housed within NJDOH’s Environmental Chemistry Laboratory Services 
(ECLS) will participate in the method development of an expanded pesticides method for juice- and vegetable- 
based beverages. The Food Emergency Response Network (FERN) methods CHE.0006 and CHE.0008 are 
excellent for the screening of food for toxins and poisons, including some pesticides, insecticides, and herbicides. 
However, these are wide ranging methods that do not include the full list of pesticides applied commercially and 
because the are primarily screening methods, they target analytes at around parts-per-million (ppm) levels. Low- 
level pesticides far below ppm levels can go undetected and remain in food items in markets. Low-level 
pesticides pose greater health risks if consumed, especially for babies or children. 
To address this food safety issue, a highly sensitive pesticide method capable of analyzing over 65 pesticides 
will be developed by the CT Laboratory. The laboratory will use its expertise and experience developing such a 
method for marijuana testing to create a method usable for food stuffs, starting with juice- and vegetable-based 
beverages. This new method will expand the number of target analytes to more than 68 pesticides, including 
most of pesticides listed in the NJ Pesticide Use Survey conducted in 2015, and will significantly lower detection 
limits down to parts-per-billion (ppb) level. This capability will provide more information for the FDA to determine 
measured pesticide levels that put the public’s health at risk. 
The CT Laboratory will use this method to support other food pesticide research by identifying and confirming 
the presence of pesticides in various foods as requested by the FDA. By conducting the work detailed in this 
proposal and managing an integrated food safety system, ECLS will be able to expand its food defense and 
safety activities while further safeguarding public health and provide the FDA with additional network capability.

## Key facts

- **NIH application ID:** 10175325
- **Project number:** 1U19FD007119-01
- **Recipient organization:** NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS
- **Principal Investigator:** Chang Ho Yu
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** FDA
- **Fiscal year:** 2020
- **Award amount:** $74,695
- **Award type:** 1
- **Project period:** 2020-09-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10175325

## Citation

> US National Institutes of Health, RePORTER application 10175325, Qualitative and Quantitative Determination of Pesticides in Beverages and Similar Food Matrices by High Performance Liquid Chromatography-Quadrupole Time-of-Flight (HPLC-QToF) Analysis (1U19FD007119-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10175325. Licensed CC0.

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