# Orbitrap Exploris 480 Basic System

> **NIH NIH S10** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2021 · $600,000

## Abstract

Project Summary
We present our proposal for the acquisition of a Thermo Scientific™ Orbitrap™ Exploris 480 mass
spectrometer that would be installed in the Proteomics Core at the Albert Einstein College of Medicine. This
instrument is critical for the performance of proteomics experiments by our NIH funded investigators. Specific
projects presented in this proposal that will benefit enormously from this instrument include research on
infectious diseases (herpes simplex virus, SARS-CoV2, Toxoplasma gondii, microsporidia, etc.), cancer
(myelodysplastic syndrome, molecular regulation and targeting of pre-cancerous and cancer stem cells in
hematopoiesis and leukemogenesis), aging (autophagy during aging, neurodegeneration), cardiovascular
diseases and fundamental cell biology (obesity, mechanisms of cell death, chromatin, cell signaling). The
Einstein Proteomics Core requires this instrument to replace a Thermo Scientific™ Orbitrap™ Velos. The
Orbitrap Velos was acquired in 2010, and it has been the only proteomics-fitted instrument for the Core, but it
now needs to be replaced as by the end of 2020 it will no longer be serviced by the vendor. The laboratory
space of the proteomics facility has recently been completely renovated and Dr. Simone Sidoli was hired to
lead proteomics research at Einstein. In the last year, the proteomics laboratory ran over 2,500 samples from
approximately 50 different investigators' laboratories. The Einstein Proteomics Core is also a critical support
service for the Einstein Cancer Center, the Nathan Shock Center for excellence on Biology of Aging Research
(E-NSC) and the ERC-CFAR Einstein-Rockefeller-CUNY Center for AIDS research.

## Key facts

- **NIH application ID:** 10175521
- **Project number:** 1S10OD030286-01
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Simone Sidoli
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $600,000
- **Award type:** 1
- **Project period:** 2021-05-15 → 2022-05-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10175521

## Citation

> US National Institutes of Health, RePORTER application 10175521, Orbitrap Exploris 480 Basic System (1S10OD030286-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10175521. Licensed CC0.

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