# Orbitrap Tribrid Mass Spectrometer

> **NIH NIH S10** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $1,101,448

## Abstract

Project Summary
We request the next generation Orbitrap Tribrid Orbitrap Eclipse instrument to place in the Oregon Health &
Science University Proteomics Shared Resource (PSR). The new instrument will better serve the needs of
researchers at the university due to its greater sensitivity, more accurate quantitation using tandem mass
tagging technology, improved electron dissociation source, and FAIMS devise to increase the depth of
proteomic analysis in complex mixtures. The instrument will support new experiments at OHSU pushing the
boundaries of proteomics by: allowing the analysis of single cell proteomes, localizing post-translational
modifications and drug binding sites in membrane protein receptors, more accurately and sensitively
measuring differential protein abundance in complex tissue and cellular lysates, measuring newly synthesized
proteins in tissues isolated by laser-capture micro-dissection, performing hydrogen/deuterium exchange
measurements, and refining cryo-EM derived protein structures using chemical cross-linking experiments. The
instrument will support the study of a wide range of diseases, including cancer, cataracts, glaucoma, drug
addiction, and hearing loss. The instrument will allow the PSR to expand its services to a growing group of
proteomics researchers at the university who need access to the most advanced mass spectrometry
instrumentation to support their research needs.

## Key facts

- **NIH application ID:** 10175686
- **Project number:** 1S10OD028533-01A1
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** LARRY L DAVID
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,101,448
- **Award type:** 1
- **Project period:** 2021-09-10 → 2022-09-09

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10175686

## Citation

> US National Institutes of Health, RePORTER application 10175686, Orbitrap Tribrid Mass Spectrometer (1S10OD028533-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10175686. Licensed CC0.

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