# Bruker timsTOF pro LC-MS system

> **NIH NIH S10** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $599,913

## Abstract

Project Summary_Abstract
We are applying for funds for a Bruker timsTOF Pro trapped ion mobility mass spectrometer LC-
MS system. This LC-ion mobility MS systems offers superior resolution to alternative systems
providing much deeper metabolomics, lipidomics and exposome screening capabilities than
classic LC-accurate mass MS/MS instruments. With the enhanced performance of the requested
Bruker timsTOF Pro LC-MS system, structurally similar lipids and other compounds can be
accurately detected and identified. Such system is urgently needed to fill gaping unmet needs by
the biomedical community here at UC Davis. We have identified 8 major users for this instrument
for 80% of time usage and suggest a 20% time usage by the UC Davis metabolomics core to
work on recharge-based projects for minor users.
By providing our infrastructure and technical expertise on LC-MS metabolomics, we project a
diverse and long-term collaborations with our users. The common thread across all projects is
that chemical complexities are too large to be resolved ‘in depths’ by current LC-accurate mass
MS/MS alone. Users need to get to the next stage to solve their research problems adequately.
Projects that need for ion mobility are such as: environmental health (Young: deeper MS/MS
coverage for non-targeted screening, van Winkle: higher resolution for oxidized lipids), cancer
metabolism (Carraway: improved sensitivity and resolution for BMP and PG lipidomics in
organelles, Chen: improved resolution of oxysterol isomers), diurnal cycles (Chiu: resolving
isobaric and isomeric triacylglycerides), nutritional interventions (Stanhope: resolving urinary
polyphenols), methods in compound identification (Fiehn: improving confidence in structure
annotations by CCS values) to gut microbiome changes (LaSalle: interaction of gut-brain axis in
Rett syndrome, resolution of biogenic amines in fecal matter). All these projects have in common
that they have hit roadblocks in our ongoing collaborations with respect to capabilities of our
current instrumentation at the WCMC that lack the added power of ion mobility separation despite
our exquisite capabilities in accurate mass analyses.

## Key facts

- **NIH application ID:** 10175940
- **Project number:** 1S10OD030253-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Oliver Fiehn
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $599,913
- **Award type:** 1
- **Project period:** 2021-06-15 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10175940

## Citation

> US National Institutes of Health, RePORTER application 10175940, Bruker timsTOF pro LC-MS system (1S10OD030253-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10175940. Licensed CC0.

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