BIOLOGICAL TESTING FACILITY - CONTRACEPTIVE TARGET WEB APPLICATION

NIH RePORTER · NIH · N01 · $110,033 · view on reporter.nih.gov ↗

Abstract

One major obstacle in early phase non-steroidal contraceptive discovery and development is limited by known targets and readily accessibility of this information. It is important to facilitate the discovery, curation and availability of contraceptive targets with the aim of developing new approaches to advance next generation of safe contraceptive drug/device. To alleviate this obstacle, bioinformatics driven approach to identify and curate those targets from the existing databases as well as from literature was established. To further allow easy accessibility and friendly user interface for this database, a web application is needed. The Biological Testing Facility has bioinformatics and web design and application capability to achieve this task, in addition to permit rapid evaluation (in vitro and in vivo) of new compositions of matter to the target, efficacy evaluation, safety/ toxicology assessment, drug formulations, delivery systems, and devices for contraceptives followed by clinical batch preparation/ release and continued stability testing of drugs to be evaluated in clinical trials. The BTF provides overall project management and the capabilities to support all phases of novel target product identification, drug discovery/ optimization, preclinical activities and development of contraceptives and associated tasks leading to the filing of investigational new drug (IND) applications

Key facts

NIH application ID
10176115
Project number
275201500002I-P00005-27500008-1
Recipient
SRI INTERNATIONAL
Principal Investigator
TOUFAN PARMAN
Activity code
N01
Funding institute
NIH
Fiscal year
2020
Award amount
$110,033
Award type
Project period
2017-09-27 → 2020-09-26