# UCSF Liver Center

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $1,187,023

## Abstract

PROJECT SUMMARY/ABSTRACT – UCSF LIVER CENTER
The Liver Center of the University of California, San Francisco (UCSF) is an interdisciplinary consortium of 59
basic and clinical scientists dedicated to understanding liver biology and contributing new knowledge about the
pathophysiology and treatment of liver diseases. The overarching theme of the center is “translating science
to benefit patients with liver disease.” The Center's research base is made up of 40 individuals: these
investigators receive $21 million dollars in liver-related research funds annually (direct costs). The research
base of the Center is evenly split between practicing physicians and non-physicians. Their research is
categorized into three focus areas. One focus area is entitled Liver Injury, Repair & Transplantation: this group
includes scientists who study liver immunology as well as clinician-investigators who study the epidemiology,
management and outcomes of chronic liver disease. Second is Liver Cell Biology, Plasticity & Transformation:
this area is home to scientists who study cellular responses to liver injury such as toxicity and fibrosis, as well
as cell growth in contexts ranging from developmental biology to cancer. Third is Hepatic Metabolism &
Metabolic Derangements: members in this category study basic aspects of nutrient and xenobiotic metabolism
as well as the mechanisms, diagnosis and outcomes of fatty liver disease. Across all focus areas, research
spans bench to bedside. More than 75% of Center members perform research directly with human subjects or
human materials. A major goal of the Liver Center is to promote research excellence and accelerate
research progress in hepatology. As it continues in 2018-2023, the Center will accomplish this goal by
supporting three Biomedical Research Cores: (1) Cell Biology, (2) Liver Immunology & Cell Analysis and (3)
Pathology & Imaging. The Center also operates a separate Clinical Component, which offers biostatistics
services and is being expanded to include support for biospecimen procurement, storage and retrieval. A
second goal of the Liver Center is to foster a vibrant community of liver researchers at UCSF. In this case
the strategy will be to stimulate scientific exchange through an Enrichment Program that features seminars by
local and visiting scientists, mini-symposia highlighting specific member constituencies, and an annual 1-day
symposium featuring the progress of the entire group. Throughout the year the Center's Administrative Core
will maintain member connections and keep them informed of new developments through newsletters and a
comprehensive website. A third goal of the Center is to sustain a trajectory of growth in liver research by
developing promising new investigators. Several means will be used to achieve this end. First, the Center
will continue its Pilot/Feasibility Program, which provides seed money to junior investigators and scientists new
to investigative hepatology. This award program is...

## Key facts

- **NIH application ID:** 10176449
- **Project number:** 5P30DK026743-39
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** JACQUELYN J. MAHER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,187,023
- **Award type:** 5
- **Project period:** 1996-12-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10176449

## Citation

> US National Institutes of Health, RePORTER application 10176449, UCSF Liver Center (5P30DK026743-39). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10176449. Licensed CC0.

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