# MOLECULAR AND CELLULAR BASIS FOR DIGESTIVE DISEASES

> **NIH NIH P30** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2021 · $1,184,071

## Abstract

PROJECT SUMMARY - OVERALL
This application is for continued support of the Vanderbilt Digestive Disease Research Center (VDDRC). Our
long-term objective is to develop a deeper understanding of gastrointestinal pathophysiology in order to reveal
new disease mechanisms and identify novel therapeutic targets. Our vision is to continue to inspire interest in
the study of digestive diseases and perform paradigm-shifting science that translates to benefit for the patients
and communities we serve. The VDDRC is multidisciplinary, including faculty in 14 different academic
departments with 84 investigators (54 full members and 30 associate members). The Aims of the VDDRC are
to: 1) promote digestive diseases research in an integrative, collaborative, and multidisciplinary manner; 2)
attract new investigators to the study of these disorders; 3) enhance the innovative research capabilities of
members; and 4) promote the career development of junior investigators. The overarching VDDRC theme is
the study of microbial and host constituents that impact digestive disease pathobiology within the context of
inflammation and the environment and investigative member interests fall into three interactive areas of study:
1) Gastrointestinal Infections and Injury; 2) Progenitor Cells, Development, Regeneration, and Pre-malignant
Lesions; and 3) Obesity, Metabolism, and Nutrition. The VDDRC contains four core research laboratories to
support members: 1) Flow Cytometry Core, 2) Preclinical Models of Digestive Diseases Core, 3) Cell Imaging
Core, and 4) Mass Spectrometry/Proteomics Core. These cores are well engrafted into our Center to provide
investigators working on digestive disease-related research with the latest advances in technology, to actively
promote collaborations, and to aid in experimental design and interpretation of results. Based directly on
investigator demand, we have now expanded our core services by adding organoid development to the
Preclinical Models of Digestive Diseases Core, and created the VDDRC Academy of Investigators as a
Component of the Enrichment Program to provide career development and support to junior investigators. The
VDDRC supports a Pilot/Feasibility Program including a university-supported translational project, a dual-
funded VDDRC-Clinical and Translational Science Award clinical project, and a Young Investigator Award
Program to foster participation of beginning and seasoned investigators in research related to digestive
diseases. The Administrative Core also contains Biostatistical and Enrichment Programs and oversees the
financial management and operation of the VDDRC.

## Key facts

- **NIH application ID:** 10176457
- **Project number:** 5P30DK058404-20
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** RICHARD M. PEEK
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,184,071
- **Award type:** 5
- **Project period:** 2002-06-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10176457

## Citation

> US National Institutes of Health, RePORTER application 10176457, MOLECULAR AND CELLULAR BASIS FOR DIGESTIVE DISEASES (5P30DK058404-20). Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/grant/nih/10176457. Licensed CC0.

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