# Basic Sciences Studies on Gene Therapy of Blood Diseases

> **NIH NIH T32** · INDIANA UNIVERSITY INDIANAPOLIS · 2021 · $87,201

## Abstract

Project Abstract
This is a vastly revised competitive renewal of NIH T32 HL-07910 entitled: “Basic Science Studies on Gene
Therapy of Blood Diseases” which is in its 20th year of funding. The discipline of gene therapy has made clinical
advances, but is still an emerging clinical field that has not come close to yet realizing its potential. To continue
to advance the field in quality of vector transduction and engrafting vector-transduced hematopoietic stem,
progenitor and other carrier cells, we must train the next generation of dedicated pre-doctoral students and post-
doctoral/clinical fellows. Our aim is to continue to train this next generation of scientists in the clinically-relevant
medical area of gene transfer for effective modulation of normal and abnormal cell growth and for gene therapy
to correct blood diseases. We request 4 pre- and 5 post-doctoral slots as allotted in the last competitive renewal.
We have an outstanding group of 25 very productive, interactive, well-respected and NIH funded investigators
as mentors with their primary and/or secondary faculty appointments in 10 departments of the medical school.
These mentors have over their career trained a total of 241 pre-doctoral PhD and 412 post-doctoral students,
and have published more than 3,500 papers (2798 original refereed, and 709 reviews/book chapters), many with
their trainees. Since the competitive renewal of this program in 2014, we were able to train and/or were in the
process of training 10 pre and 10 post-doctoral students, who have published 72 papers [40 (Pre-Doc) and 32
(Post-Doc)]. The Program Director (PD) has trained 21 pre-doctoral and 57 postdoctoral/clinical fellows, has
published 795 papers, cited over 63,000 times with an H-Factor of 120, and been continuously funded by the
NIH since 1978. He is a recognized authority on hematopoietic stem/progenitor cells, and regulation of
hematopoiesis. The Co-PD, is a well-recognized and well-funded productive investigator in the area of gene
transfer/therapy, and hematopoiesis during disease who has trained numerous students and fellows. The PD
and Co-PD have had their work translated for clinical benefit and have extensive administrative experience. They
have worked for many years in the area of gene transfer to enhance gene therapy. The majority of our trainees,
since initial funding of this grant in 1999, have gone on to careers in academia and other research intensive
areas of employment. Training of our pre- and post-doctoral students entails one-on-one interactions, committee
and group mentorship, lab meetings, a special seminar series, and journal club in the area of this training
program, didactic courses, ethical training, presentations at scientific meetings and expectations for them to
publish in scientific and medical journals, to present their work at national and international meetings and to
become productive independent investigators whose work will benefit healthcare in general and gene
transfer/ge...

## Key facts

- **NIH application ID:** 10176554
- **Project number:** 5T32HL007910-22
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** David W Clapp
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $87,201
- **Award type:** 5
- **Project period:** 1999-07-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10176554

## Citation

> US National Institutes of Health, RePORTER application 10176554, Basic Sciences Studies on Gene Therapy of Blood Diseases (5T32HL007910-22). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10176554. Licensed CC0.

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