# TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responses

> **NIH NIH P20** · UNIVERSITY OF NEW HAMPSHIRE · 2020 · $230,222

## Abstract

The innate immune response to pathogens involves the expression and secretion of inflammatory 
cytokines that act to facilitate eradication of the infecting pathogen. The dysregulation of cytokine 
production (chronic inflammation) can have negative effects on the host. Therefore, a fundamental 
understanding of the molecular mechanisms regulating inflammation is essential for the development of 
therapeutic approaches for inflammatory disorders. We identify a novel role for the transcription factor 
GLI3 in regulating cytokine expression in response to TLR-TRIF signaling. GLI3 KO in monocytes induces 
a phenotype that indicates GLI3 associates with inflammatory pathways in response to TLR-TRIF 
stimulation. In this proposal, we will further elucidate the role of GLI3 in regulating cytokine expression in 
monocytes and explore the relevance of this regulation in inflammatory responses.

## Key facts

- **NIH application ID:** 10176690
- **Project number:** 5P20GM113131-04
- **Recipient organization:** UNIVERSITY OF NEW HAMPSHIRE
- **Principal Investigator:** Sherine F. Elsawa
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $230,222
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10176690

## Citation

> US National Institutes of Health, RePORTER application 10176690, TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responses (5P20GM113131-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10176690. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*