# An Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-II

> **NIH NIH S10** · NEW YORK STRUCTURAL BIOLOGY CENTER · 2021 · $1,794,700

## Abstract

Project Summary
The New York Structural Biology Center (NYSBC) owns and operates the NYX beamline
at the National Synchrotron Light Source II (NSLS-II) which is located at the Brookhaven
National Laboratory (BNL) and operated for the benefit of the member institutions of the
NYSBC and the community of non-consortium-member structural biologists. We seek
funds to acquire a Dectris Eiger2 XE 9M X-ray detector for macromolecular
crystallography. This advanced, high-speed readout of the detector will significantly
increase the throughput of samples and therefore increase the number of projects that can
be prosecuted in a set amount of time. The high frame rate will allow us to perform
advanced crystallographic methods that are not possible with our current experimental
setup, such as serial crystallography, ultra-fast rastering and potentially outrunning
radiation damage during data collection. NYX has been operating with a prototype pixel
array detector from Area Detector Systems Corporation (HF-4M) since its inception at
NSLS-II. While the data quality from this detector has been comparable with other
available detectors, ADSC ceased to operate several years ago with the result that the
detector is no longer serviceable and is starting to fail. In order to remain valuable to
users, it is imperative that we replace the ADSC HF-4M with a modern pixel array
detector with the expectation that it will remain useful and serviceable for the next 8-10
years. Of particular importance is performing this upgrade prior to the temporary
shutdown of the Advanced Photon Source for a facility upgrade in 2022 when the
demand for synchrotron access for NIH-funded projects is expected to increase
dramatically. Having this detector in place in 2021 will allow NYX to significantly
enhance the NIH-funded research programs of the NYSBC consortium members, non-
consortium members as well as be fully prepared to provide uninterrupted access to
NIH-funded projects due to the temporary closure of the APS.

## Key facts

- **NIH application ID:** 10176813
- **Project number:** 1S10OD030394-01
- **Recipient organization:** NEW YORK STRUCTURAL BIOLOGY CENTER
- **Principal Investigator:** KEVIN P BATTAILE
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,794,700
- **Award type:** 1
- **Project period:** 2021-04-01 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10176813

## Citation

> US National Institutes of Health, RePORTER application 10176813, An Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-II (1S10OD030394-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10176813. Licensed CC0.

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