# Electroanatomical Mapping for Shared Translational Research

> **NIH VA IS1** · VA VETERANS ADMINISTRATION HOSPITAL · 2021 · —

## Abstract

PROJECT SUMMARY / ABSTRACT
 We request funds to acquire the St Jude/Abbott Ensite Precision Electroanatomical Mapping
System to facilitate current and new collaborative translational research at Hunter Holmes McGuire VA
Medical Center, and collaborations with investigators at Virginia Commonwealth University. This state-of-the-
art system can perform diagnostic cardiac electrophysiologic (EP) and hemodynamic studies, high density
arrhythmia mapping and therapeutic ablation. 1 Although designed for cardiac and vascular studies, it can be
applied to record and stimulate electrical signals in the central and peripheral nervous systems. 2 Its primary
role is to replace and upgrade out-of-date equipment critical to core VA-funded research, while expanding
avenues of investigation across different specialties (cardiology, anesthesia, neurology, pharmacy) and
collaboration with our university affiliate, Virginia Commonwealth University.
 The equipment’s specific capabilities include to record electrical signals, measure pressure
waveforms, electrically stimulate target tissue, apply radiofrequency ablation, perform automated computerized
high density 3-dimentional mapping of complex electrical activations during cardiac arrhythmias. Due to its
broad capabilities, it can benefit researchers across different subspecialties. In contrast, the current system
(GE Prucka CardioLab) has more limited diagnostic capabilities (recording and stimulation but no ablation),
and has an out of date manual, sequential mapping system (vs automated) which makes it inadequate for
current and future research proposals funded by VA, and extramural agencies such as NIH and AHA.
 Core VA research projects will investigate novel therapies for postoperative atrial fibrillation (POAF), 3
premature ventricular contraction-induced cardiomyopathy (PVC-CM), 4 5 demyelinating and
neurodegenerative conditions 6 and cardioprotective and antiarrhythmic therapies targeted at improving
function of mitochrondria, i.e. the cell’s energy sources, in ageing and ischemia related heart disease. 7 Other
studies with direct translational applications include the testing of different ablation energies and techniques to
optimize safe and effective ablation in human arrhythmia, 8 and testing different anesthesia types in diseased
heart models in order to optimize their application in patients.
 VCU collaborations will utilize the equipment to determine the anti-arrhythmic and cardioprotective
mechanisms of novel or ‘repurposed’ drugs that target inflammatory cytokines and their receptors to protect
against ischemia-related injury and heart failure. 9,10

## Key facts

- **NIH application ID:** 10177076
- **Project number:** 1IS1BX005574-01
- **Recipient organization:** VA VETERANS ADMINISTRATION HOSPITAL
- **Principal Investigator:** Alex Y Tan
- **Activity code:** IS1 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2021
- **Award amount:** —
- **Award type:** 1
- **Project period:** 2020-10-01 → 2021-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177076

## Citation

> US National Institutes of Health, RePORTER application 10177076, Electroanatomical Mapping for Shared Translational Research (1IS1BX005574-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10177076. Licensed CC0.

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