# Vevo 3100 ultrasound scanner and PV loop system

> **NIH NIH S10** · THOMAS JEFFERSON UNIVERSITY · 2021 · $746,509

## Abstract

The Jefferson High Frequency Ultrasound Core Facility provides preclinical imaging services to
investigators across Thomas Jefferson University (TJU). A Vevo 2100 ultrasound system (FujiFilm
VisualSonics Toronto, Ontario, Canada), which was acquired in 2011 under an S10 awarded to Dr
Flemming Forsberg (the PI of this application) enables noninvasive high-resolution imaging as well as
opto-acoustic quantification of the tissue microenvironment. Frequently used applications include
analysis of multiple cardiac functional parameters including ejection fraction, fractional shortening,
dimensions, volumes, wall thickness, etc., orthotopic tumor and organ volume quantification, vascularity
monitoring, nonlinear contrast imaging, ultrasound-triggered drug delivery work, contrast-enhanced
photoacoustic imaging, and quantification of tissue oxygenation levels. Animal models we have imaged
range from fruit fly larvae to rabbits, but primarily consist of mice and rats. Over the last decade, the
system has been used by more than 20 Jefferson faculty members. These have resulted in a countless
publications and ongoing research collaborations. At the current time, the system is utilized by 14 NIH
funded investigators and its operation is crucial to the progress of these grants. These investigators
span multiple TJU departments including Radiology, Medicine, Orthopedic Surgery, and Pathology.
However, VisualSonics has announced that it will no longer provide service on the 2100 model line.
Hence, this application requests funding to purchase the newer Vevo 3100 LAZR-X system, which will
provide reliable small animal scanning capabilities for the foreseeable future, while also offering
significant technological upgrades in multiple areas over the 2100 model. Moreover, we will acquire a
pressure-volume loop recording system from Data Sciences International, which uses different
implanted monitors to detect in vivo real-physiological parameters, and, most importantly, can be directly
linked together with the Vevo 3100 system. All the selected major users of this system have ongoing
and well-funded federal research programs that have the current and future needs of in vivo imaging of
animal models for translational applications in cancer biology, cardiovascular disease and emerging
molecular therapies. The Vevo 3100 ultrasound scanner together with the pressure-volume loop
recording system is truly the state-of-the-art in vivo imaging and measurement system dedicated to, and
without equal for, small animals. Consequently, these systems will be a major boost to the extensive,
federally supported, small animal research efforts at TJU.

## Key facts

- **NIH application ID:** 10177118
- **Project number:** 1S10OD030483-01
- **Recipient organization:** THOMAS JEFFERSON UNIVERSITY
- **Principal Investigator:** Flemming Forsberg
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $746,509
- **Award type:** 1
- **Project period:** 2021-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177118

## Citation

> US National Institutes of Health, RePORTER application 10177118, Vevo 3100 ultrasound scanner and PV loop system (1S10OD030483-01). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10177118. Licensed CC0.

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