# ICP-QQQ

> **NIH NIH S10** · JOHNS HOPKINS UNIVERSITY · 2021 · $349,507

## Abstract

Project Summary/Abstract:
The overall goal of this proposal is to acquire funds to purchase a triple quadrupole mass spectrometer and a
new microwave digestor to replace a 14-year old Agilent 7500ce ICP-MS and a MARS5 microwave. The funds
will be used to purchase an Agilent 8900 ICP-QQQ system that can be coupled with our existing Agilent 1260
HPLC system which will be dedicated to support NIH-funded investigators requiring quantitative metal analysis,
including metal speciation. A group of investigators (6 major, 5 minor) has been identified whose research
(75.1% NIH-funded) will greatly benefit from analyses performed with the requested instrumentation. The Trace
Metals Lab (TML) in the Department of Environmental Health and Engineering at Johns Hopkins Bloomberg
School of Public Health houses the only ICP-MS in the medical campus, which includes the School of Medicine
(SOM) and the School of Public Health. The TML has been providing accurate, sensitive, and reliable trace metal
analysis for health-related research since 2006. This shared resource provides funded investigators with
technical expertise and access to large equipment for quantitative analysis of trace metals. The JHU TML is
used heavily by NIH-funded grants supporting research that ranges from exposure to metals from e-cigarettes
(R01), evaluation of Magnetic Hyperthermia Therapy (MHT) against infiltrating glioblastoma (R01) and liver
cancer tumors (R01), assessment of arsenic exposure on immune responses to influenza (R01), Arsenic and
other metal exposures in American Indian communities (R01), among others. The research that will benefit
from this instrumentation will have enormous impacts on the disciplines of Medicine and Public Health. With ICP-
QQQ, HPLC, microwave digestion, and Single Particle analysis capabilities, our lab will continue to advance the
translation of basic biomedical research to treatments and cures, and will also contribute to prevention through
strategies for reducing exposure to environmental pollutants for diverse populations. The number of basic and
clinical investigators requiring analytical services of trace metals has experienced a rapid growth. As a result,
usage of the existing ICP-MS instrument is currently at full capacity. The new instrumentation will also benefit
studies that are not currently NIH funded, pilot projects to collect data for NIH grants, and student research
projects. The ICP-MS capability of the JHU TML will also contribute to the long-range biomedical research goals
of the Johns Hopkins University. This instrumentation will benefit research to understand basic cellular toxicity,
risk factors for infection, develop important new therapeutic strategies against cancer, and advance our
understanding of stroke mechanisms, heart disease, cancer survival, and immune responses. As outlined in this
application, acquisition of this equipment will make this technology available to a large number of investigators,
continuing with the goal...

## Key facts

- **NIH application ID:** 10177184
- **Project number:** 1S10OD030355-01
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Ana Maria Rule
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $349,507
- **Award type:** 1
- **Project period:** 2021-07-15 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177184

## Citation

> US National Institutes of Health, RePORTER application 10177184, ICP-QQQ (1S10OD030355-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10177184. Licensed CC0.

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