# Replacement of an outdated 600 MHz NMR CryoProbe system

> **NIH NIH S10** · UNIV OF MARYLAND, COLLEGE PARK · 2021 · $341,283

## Abstract

NIH Shared Instrumentation Grant (SIG) Program, PAR-20-113
Project Summary/Abstract:
To sustain and expand the strong high field Biomolecular NMR research programs at the
University of Maryland, College Park (UMCP), we are applying for a SIG grant to replace
an aging Cryoprobe system of a Bruker 600 MHz Nuclear Magnetic Resonance (NMR)
spectrometer at the Biomolecular NMR Facility. The components we propose to purchase
are 1) a 5th generation CryoPlatform, 2) BNSL/a Nitrogen re-liquefication accessary, 3) a
Cryo-TCI H&F probe, together with a BBFO room temperature probe, 4) a SampleCase
system.
The 600 MHz NMR equipped with a Cryo-TXI probe, installed in 2002, is the first high
field NMR on UMCP campus. The spectrometer is a powerful tool to study chemical and
biomolecular structures, molecular dynamics and affinities, as well as to analyze
compounds in low concentration due to the Cryoprobe’s high sensitivity. Since its
installation, the spectrometer has been daily serving graduate students and faculty
members in various fields on campus, and periodically users from neighboring academic
and government research institutes. It has been an essential instrument to several
principal investigators (PIs) with NIH funded programs. However, the spectrometer has
started to have increasing down time in recent years due to frequent repairs of its aging
CryoPlatform and Cryo-TXI probe, disrupting NMR research activities of users.
We believe it is urgent to address the reliability issue of the Cryoprobe system of the
spectrometer to ensure the sustainability and performance of the system. The proposal
for replacement is strongly supported by NIH funded PIs as well as other faculty members
at UMCP. The SIG grant would provide an opportunity to rescue the aging instrument as
well as to enhance the performance and capability of the instrument. If awarded, the up-
to-date instrument will bring following benefits to UMCP NMR community: (1) Ensuring
the advance of several NIH funded research programs. (2) Inspiring new Biomolecular
NMR research interests. (3) Improving productivity and efficiency. (4) Providing hands-on
learning and working experience to graduate students and postdocs (5) Drastically
reducing liquid nitrogen consumption/cost.

## Key facts

- **NIH application ID:** 10177236
- **Project number:** 1S10OD030350-01
- **Recipient organization:** UNIV OF MARYLAND, COLLEGE PARK
- **Principal Investigator:** Daoning Zhang
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $341,283
- **Award type:** 1
- **Project period:** 2021-04-15 → 2023-04-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177236

## Citation

> US National Institutes of Health, RePORTER application 10177236, Replacement of an outdated 600 MHz NMR CryoProbe system (1S10OD030350-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10177236. Licensed CC0.

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