# UAB U-SPECT6CTUHROI Imager

> **NIH NIH S10** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2021 · $750,000

## Abstract

The broad and long-term objectives of this application is to provide the proposed U-
SPECT6CTUHROI instrumentation to the UAB research infrastructure to conduct simultaneous
functional and anatomic imaging over a wide array of biological and preclinical applications. The
SPECT6CTUHROI system allows for precise anatomic information in 3D by ultra-high resolution
(4 voxel) computed tomography (CT) that is coupled with functional imaging with a large number
of agents (fluorescent, bioluminescent, and/or radioactive) in the same animal at the same time,
providing broad applicability to biological applications. Co-localized functional and anatomic
information provides superior understanding of disease pathogenesis and therapeutic response,
accelerating research progress, with techniques not yet available to the UAB community.
Hence, the scanner creates a paradigm shift in animal research capabilities for our research
community. Longitudinal repeated measure designs will be facilitated, improving reproducibility,
reducing animal utilization, and empowering more detailed understanding of tissue-level
pathogenesis. The equipment will be utilized by a large group of NIH-funded, established, and
collaborative investigators spanning multiple disease areas, including respiratory and
environmental diseases, kidney disease, and microbiological applications. The multi-modality
tool will be integrated into a highly productive and multi-disciplinary research infrastructure, and
will improve the understanding and treatment of disorders that affect a wide array of patients.
The instrument will be managed by the NIH supported Small Animal Imaging Facility, and co-
supported by the Multi-disciplinary Respiratory Imaging Core, the Gregory Fleming James
Cystic Fibrosis Research Center, and the UAB-UCSD O'Brien Center for Acute Kidney Injury,
providing a strong base of users, expertise in image acquisition and analysis, and several
complementary imaging techniques housed in these facilities. The strong and sustainable
management plan will assure access to the primary user base and beyond in a sustainable
platform intended to foster multi-disciplinary research of substantial impact.

## Key facts

- **NIH application ID:** 10177258
- **Project number:** 1S10OD030465-01
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** Steven Mark Rowe
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $750,000
- **Award type:** 1
- **Project period:** 2021-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177258

## Citation

> US National Institutes of Health, RePORTER application 10177258, UAB U-SPECT6CTUHROI Imager (1S10OD030465-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10177258. Licensed CC0.

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