# Cueing COVID-19: NLM Administrative Supplement for Research on Coronavirus Disease 2019

> **NIH NIH R01** · MEDSTAR HEALTH RESEARCH INSTITUTE · 2020 · $75,000

## Abstract

PROJECT SUMMARY
The variability and the complexity of the data needed for clinical care requires clinicians to accurately and
efficiently recognize COVID-19 amongst individuals, ranging from asymptomatic infection to multiorgan and
systemic manifestations. COVID-19, like sepsis, involves different disease etiologies that span a wide range of
syndromes (e.g., initial, inflammatory, hyperinflammatory response). Because patients can present with mild,
moderate, or severe symptoms, clinicians must both identify the disease stage and optimal treatment. The
factors that trigger severe illness in COVID-19 patients are not completely understood. Like other complex,
challenging diagnoses, clinicians in the trenches struggle to diagnose and treat patients using data available in
the electronic health record (EHR). In our current NIH NLM R01 “Signaling Sepsis: Developing a Framework to
Optimize Alert Design”, we created sepsis specific enhanced visual display models that outranked preference
and performance when compared with the usual care of fragmented, non-directed information gathering. For this
supplement, we propose the design and development of COVID-19 diagnosis and clinical management
enhanced visual display models to support clinicians’ recognition of critical phases in COVID-19
diagnosis and treatment decisions. In order to create the models, we will identify relevant diagnostic and
treatment data elements that will include clinical characteristics, laboratory results, and radiology results (e.g.,
chest CT). Our project will survey emerging models of COVID-19 and its stages, and ensure our models are
congruent with best practices that emerge as our knowledge as a medical community evolves. The models
provide an EHR based method to mine clinical data to identify the presence of COVID-19 which supports the
variety of ways in which COVID-19 presents, availability of data elements, accuracy of diagnostic tests, and the
highly infective nature of the disease. Specific Aim 1: To identify emerging patient-specific clinical features of
COVID-19 and testing analytics to present critical information for COVID-19 diagnosis and clinical management.
Elements include the characteristics listed above (e.g., symptoms, co-morbidities) plus COVID-19 specific test
results, including data specific to the tests’ positive and negative predictive values. Specific Aim 2: To develop
an EHR embedded CDS tool using our COVID-19 enhanced visual display models using synthesized information
obtained through the NLM parent grant and Specific Aim 1. Evaluate the technical feasibility and usability of the
novel COVID-19 CDS tool. Why It Matters: During a pandemic, there’s no room for ambiguity as clinicians are
required to comb through the EHR. The ability to better visualize and interpret EHR data supports optimal
diagnosis and clinical management. Our enhanced visual display models will support clinicians as they evaluate
demographic factors, underlying conditions, and comorbi...

## Key facts

- **NIH application ID:** 10177308
- **Project number:** 3R01LM012300-04S1
- **Recipient organization:** MEDSTAR HEALTH RESEARCH INSTITUTE
- **Principal Investigator:** Kristen Elizabeth Miller
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $75,000
- **Award type:** 3
- **Project period:** 2020-07-10 → 2021-07-09

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177308

## Citation

> US National Institutes of Health, RePORTER application 10177308, Cueing COVID-19: NLM Administrative Supplement for Research on Coronavirus Disease 2019 (3R01LM012300-04S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10177308. Licensed CC0.

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