# Quadrupole Orbitrap Hybrid Mass Spectrometer for Proteomics

> **NIH NIH S10** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2021 · $772,652

## Abstract

PROJECT SUMMARY
This proposal is requesting funds to acquire a Quadrupole Orbitrap Hybrid Exploris 480 Mass Spectrometer
(ThermoScientific) for the Medical University of South Carolina Mass Spectrometry Facility and Proteomics
Center to support our NIH funded investigators’ efforts to discover mechanisms of protein regulation involved in
cardiovascular disease, cancer, immunotherapy, digestive disease, diabetes, musculoskeletal diseases,
addiction, and neurological diseases. Our users are relying on ThermoScientific Orbitrap LC-MS/MS ETD
systems purchased in 2012 and 2018 (S10 OD010731 and S10 OD025126, PI: Lauren Ball) to characterize the
impact of drugs/hormones, genetic alterations, and disease on changes in protein expression, protein
interactions, and post-translational modifications. With the recent funding successes of new users and an
increased number of NIH awards to our major user group, we are experiencing a greater demand for instrument
time. To address the increased need for quantitative proteomic experiments and provide highly-sensitive,
targeted-proteomic capabilities for the analysis of post-translationally modified proteins from limited amounts of
sample, we are requesting the state-of-the-art Quadrupole Orbitrap Hybrid Exploris 480 MS. The requested
instrumentation is to be housed in the Mass Spectrometry Facility, a University Research Resource Facility, to
provide quantitative proteomic capabilities to investigators at the Medical University of South Carolina and other
academic research institutions in South Carolina.

## Key facts

- **NIH application ID:** 10177354
- **Project number:** 1S10OD028692-01A1
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Lauren Elizabeth Ball
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $772,652
- **Award type:** 1
- **Project period:** 2021-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177354

## Citation

> US National Institutes of Health, RePORTER application 10177354, Quadrupole Orbitrap Hybrid Mass Spectrometer for Proteomics (1S10OD028692-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10177354. Licensed CC0.

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