# ShEEP Request for an X-Ray Irradiation System

> **NIH VA IS1** · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · 2021 · —

## Abstract

The requested equipment is an X-RAD 320 large chamber self-contained X-ray system from
Precision X-ray Inc. This equipment would significantly advance the existing research of a large
number of VA researchers, enable the extension of current studies in new directions and foster
collaborations among multiple VA investigators. The irradiator has built in functionality to
perform both X-ray irradiation as well as bioluminescent imaging of small animals. There is
currently no equipment at the Cleveland VA Medical Center to perform irradiation of any sort for
research studies or bioluminescent imaging of small animals. This instrument will play a major
role in enabling VA research to be performed on site at the Cleveland VA Medical Center that
currently is not feasible and can only be performed off site. Acquisition of the irradiator will
greatly enhance Cleveland VA research efforts in a variety of fields including cancer
research, neurological research and studies on SARS-COV2. In addition to being the only
instrument that incorporates imaging and irradiation into a single device, a major advantage
of this instrument is its safety. Unlike radioactive irradiators that have major safety and
regulatory concerns, this X-ray based instrument is safe and reliable. The Cleveland VA
research program has 4 Major and several minor users whose research will be significantly
impacted by this instrument. In addition, it is expected that the availability of this currently
unavailable technology will help foster new directions for other local VA researchers. All of
the users have strong track records of VA and other national funding that will help support the
use of this machine. The PI will help lead the efforts to supervise and maintain the equipment as
well as train other users. Overall, the purchase of the X-RAD 320 irradiator will fill a major unmet
need for many VA researchers and facilitate future research efforts.

## Key facts

- **NIH application ID:** 10177392
- **Project number:** 1IS1BX005570-01
- **Recipient organization:** LOUIS STOKES CLEVELAND VA MEDICAL CENTER
- **Principal Investigator:** David Wald
- **Activity code:** IS1 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2021
- **Award amount:** —
- **Award type:** 1
- **Project period:** 2020-10-01 → 2021-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177392

## Citation

> US National Institutes of Health, RePORTER application 10177392, ShEEP Request for an X-Ray Irradiation System (1IS1BX005570-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10177392. Licensed CC0.

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