# Ultra-sensitive multi-mode laser-scanning imaging system

> **NIH NIH S10** · WEILL MEDICAL COLL OF CORNELL UNIV · 2021 · $163,245

## Abstract

SUMMARY
This proposal request funds to acquire an ultrasensitive highly quantitative imaging platform suitable for
quantification of fluorescent, chemiluminescent, chromatic, and radioactive signals on gels, histologic slides,
well plates, and phosphor imaging cassettes for radioactivity. This application will directly support 12 NIH-
funded investigators and support and substantially expand the research supported by 24 NIH grants. Each of
these investigators has specific projects that benefits from one or more unique aspects of the Cytiva Typhoon
5 laser-scanning imager. In some cases, the experiments involve ultrasensitive quantification enabling protein
detection from exceptionally low input samples. In other instances, the Typhoon 5 enables increased
throughput and broadens the capacity for screening and discovery. In other cases, the experiments enable
quantification of radioactive signals, which is no longer available at the Weill Cornell Imaging Core facility. The
Typhoon 5 is intended to replace a nonfunctional phosphor imager. The Typhoon 5 will provide capabilities to
Weill Cornell Medicine and neighboring institutions and will be supervised by an advisory committee, overseen
by the Pharmacology Core, and will thus positively impact basic and translational NIH-funded research,
expanding chemical biology, chemical biology, and pharmacology research. The NIH-funded research
programs supported by this instrumentation has relevance to cancer, immunology, metabolism, drugs of abuse
including alcohol, neuroscience, neurodegeneration, bone disease, and other pathways.

## Key facts

- **NIH application ID:** 10177398
- **Project number:** 1S10OD030335-01
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** SAMIE R JAFFREY
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $163,245
- **Award type:** 1
- **Project period:** 2021-04-01 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177398

## Citation

> US National Institutes of Health, RePORTER application 10177398, Ultra-sensitive multi-mode laser-scanning imaging system (1S10OD030335-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10177398. Licensed CC0.

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