# Ultrasound System for Transational Research

> **NIH NIH S10** · YALE UNIVERSITY · 2021 · $589,686

## Abstract

Summary
 We are requesting funds to purchase an interventional ultrasound system (Epiq CVxi, Philips) with 2D
and 3D transthoracic, 3D transesophageal, high frequency vascular imaging probes, abdominal probe, and
non-imaging Doppler probes for a wide range of NIH funded projects. This system will replace an ultrasound
imaging system (iE33, Philips Healthcare) that has been successfully operated as a shared imaging resource
in the Yale Translational Research Imaging Center (Y-TRIC) for over 10 years. The existing system was
initially acquired as part of a NIH funded Bioengineering Research Partnership with Philips Healthcare in 2006
to develop radiofrequency (RF) based 3-dimensional (3D) echocardiography speckle tracking for
comprehensive analysis of regional myocardial strain. The existing ultrasound system has reached end of life
and was equipped with a prototype RF capture board that can no longer be serviced. The EPIQ CVxi system is
a state-of-the-art ultrasound system that includes hardware upgrades that are specifically tailored for interface
and use with our existing interventional fluoroscopic C-arm X-ray unit (Allura Xper FD20, Philips) for ultrasound
image guidance, as well as interface with our existing hybrid CZT SPECT 64-slice CT system (Discovery
NMCT570, GE Healthcare). Integration of echocardiographic images with x-ray fluoroscopy is critical for image
guided interventions in the current era of catheter-based treatment of congenital heart disease and adult
structural heart disease, ischemic heart disease, and electrophysiological interventions. Fused real-time 3D
transesophageal echocardiography and x-ray fluoroscopy is currently used for percutaneous mitral valve and
aortic valve procedures, and treatment of complex congenital anomalies. Multimodality image guided
percutaneous procedures are now replacing conventional cardiac surgery for treatment of these conditions. In
the future multimodality image fusion will help to guide intramyocardial delivery of novel therapeutics and
theranostics to the heart, including; gene therapy, stem cell therapy, or drug releasing polymer therapies. The
use of the system goes beyond application in the cardiovascular system and involves projects related to
assessment of neurovascular function, optimization of SPECT and PET imaging, treatment of hepatic cancer,
and evaluation of organs for transplantation. The system will be used for 7 major and 4 additional minor NIH
funded projects by investigators at the School of Medicine and School of Engineering and Applied Sciences.
The imaging resources within Y-TRIC and associated faculty are highly qualified to optimize the utilization of
the interventional ultrasound system and are uniquely positioned to facilitate training of the new leaders in
multimodality imaging and ultrasound guided interventions.

## Key facts

- **NIH application ID:** 10177501
- **Project number:** 1S10OD028738-01A1
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Albert J Sinusas
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $589,686
- **Award type:** 1
- **Project period:** 2021-09-15 → 2022-09-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177501

## Citation

> US National Institutes of Health, RePORTER application 10177501, Ultrasound System for Transational Research (1S10OD028738-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10177501. Licensed CC0.

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