# In Vivo Fluorescence and Bioluminescence Imager with CT

> **NIH NIH S10** · UNIVERSITY OF MARYLAND BALTIMORE · 2021 · $599,999

## Abstract

PROJECT SUMMARY
 Bioluminescent and fluorescent in vivo imaging on whole animal has become an
increasingly important and necessary tool for biomedical researchers in many fields including
cancer, neurobiology, infectious diseases and inflammation. In vivo imaging facilitates a better
understanding of disease pathology, disease monitoring, and drug development. Perkin Elmer’s
IVIS SpectrumCT measures bioluminescence, fluorescence, 2D and 3D imaging capabilities
and included an integrated low-dose and ultra-fast CT imaging. Many of the research projects
described in this application are translational in nature and will lead to new therapeutics or
better understanding of disease states. Our current system purchased in 2005 and updated in
2012 and has become unreliable leading to significant downtime of the instrument. Many of our
investigator who conduct longitudinal mice experiments have lost time, money, data and effort
due to unexpected unavailability of our current IVIS Xenogen. We have nearly 55 users of the
existing system from schools within the University of Maryland Baltimore (UMB) and various
centers of excellence. We have identified a group of 20 NIH-funded investigators with 36 NIH
and other federal grants whose individual projects would be directly and substantially benefitted
by having continued access to a reliable, state-of-the-art instrument to conduct bioluminescence
and fluorescence imaging in whole animals. Significant commitment by the institution towards
installation and sustained long-term operations has been made in order obtain the state-of-the-
art bioluminescence/fluorescence system with a built-in CT system for 3D tomography
applications. The management and operational structure for this instrument is already in place
with an outstanding technical team that strives to provide excellent service to the end users.

## Key facts

- **NIH application ID:** 10177666
- **Project number:** 1S10OD030430-01
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** Rena Lapidus
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $599,999
- **Award type:** 1
- **Project period:** 2021-06-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177666

## Citation

> US National Institutes of Health, RePORTER application 10177666, In Vivo Fluorescence and Bioluminescence Imager with CT (1S10OD030430-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10177666. Licensed CC0.

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