# Community Crystallization Resource for Biological Macromolecules

> **NIH NIH R24** · HAUPTMAN-WOODWARD MEDICAL RESEARCH INST · 2020 · $246,073

## Abstract

1R24GM12135 COMMUNITY CRYSTALLIZATION RESOURCE FOR BIOLOGICAL MACROMOLECULES
ADMINISTRATIVE SUPPLEMENT SUPPORT REQUEST
PROJECT SUMMARY/ABSTRACT
Macromolecular X-ray crystallography is one of the predominant methods used in structural
biology, accounting for ~90% of solved structures in the Protein Data Bank, the primary repository
and public database for making these three-dimensional structures of biomolecules available to
researchers in all fields. To do crystallography, we need crystals. Finding conditions in which a
macromolecule will crystallize remains a key challenge in this process, and we have focused on
solving this problem at the High-Throughput Crystallization Screening Center. The Crystallization
Center is a community resource that provides crystallization experiment set-up and imaging of a
uniquely designed set of 1,536 crystallization conditions. Information about macromolecular
crystallization is efficiently collected, so that structural investigations for the entire research
community can rapidly progress. The Crystallization Center has a robust imaging schedule that
facilitates immediate identification of positive crystallization outcomes. The unforeseen
circumstances arising due to the extended COVID-19 pandemic have disrupted the operations of
the Crystallization Center, as well as the research activities of the wide base of Crystallization
Center users. This revision application seeks funds to address this unanticipated need to maintain
operations in the Crystallization Center and to facilitate providing continuous uninterrupted
services.

## Key facts

- **NIH application ID:** 10177813
- **Project number:** 3R24GM124135-03S1
- **Recipient organization:** HAUPTMAN-WOODWARD MEDICAL RESEARCH INST
- **Principal Investigator:** Edward H Snell
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $246,073
- **Award type:** 3
- **Project period:** 2017-09-30 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177813

## Citation

> US National Institutes of Health, RePORTER application 10177813, Community Crystallization Resource for Biological Macromolecules (3R24GM124135-03S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10177813. Licensed CC0.

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