# Does medical cannabis reduce opioid analgesics in HIV+ and HIV- adults with pain?

> **NIH NIH R01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2021 · $733,464

## Abstract

Over the past decade, opioid analgesic use has doubled, becoming a leading strategy to manage chronic
pain. Simultaneously, opioid use disorder and overdoses have dramatically increased. To address this opioid
epidemic, one rapidly expanding strategy to manage chronic pain is medical cannabis. As of January 2017,
medical cannabis is legal in 28 states, and 27 states include pain as a qualifying condition. Although studies
demonstrate analgesic effects of cannabis, few have examined how medical cannabis affects opioid analgesic
use. Studies have not examined long-term medical cannabis use or compared medical cannabis products with
different Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) content. Managing chronic pain in HIV+ adults
is particularly challenging, yet few studies have focused on this population. With a high prevalence of chronic
pain, opioid analgesic use, and cannabis use among HIV+ adults, it is important to understand how, in HIV+
adults, medical cannabis use affects opioid analgesic use and HIV outcomes. Despite its potential benefits,
cannabis has potential adverse events. Few studies have examined adverse events with long-term medical
cannabis use, and none have examined adverse events specific to THC/CBD content. Our overarching goal
is to understand how medical cannabis use affects opioid analgesic use over time, with attention to
THC/CBD content, HIV outcomes, and adverse events.
 We will conduct a cohort study of 250 HIV+ and HIV- adults with (a) severe or chronic pain, (b) current
opioid analgesic use, and (c) who are newly certified for medical cannabis. Over 18 months, we will collect
data via 7 in-person visits every 3 months and 39 web-based questionnaires via cellphones every 2 weeks.
Data sources will include: questionnaires; medical, pharmacy, and Prescription Monitoring Program (PMP)
records; urine and blood samples; and qualitative interviews. Over participants’ 2-week time period (unit of
analysis), medical cannabis exposure will be the number of days of medical cannabis use (primary exposure
measure), and opioid analgesic use will be the cumulative opioid analgesic dose (primary outcome measure).
We will examine how medical cannabis use affects: 1) opioid analgesic use, 2) HIV outcomes, and 3)
adverse events. We hypothesize that (1) medical cannabis use will be associated with a reduction in opioid
analgesic use, (2) the association between medical cannabis and opioid analgesic use will differ by THC/CBD
content, (3) HIV outcomes will differ by medical cannabis use and THC/CBD content, and (4) more medical
cannabis use and higher THC (vs. CBD) content will be associated with more adverse events. In addition, we
will qualitatively explore individuals’ perceptions of how their medical cannabis use affects their opioid
analgesic use. As medical cannabis use continues to expand, and as the opioid epidemic continues to grow,
our study findings will have important individual and public health implications that hav...

## Key facts

- **NIH application ID:** 10177977
- **Project number:** 5R01DA044171-06
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** JULIA H. ARNSTEN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $733,464
- **Award type:** 5
- **Project period:** 2017-07-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177977

## Citation

> US National Institutes of Health, RePORTER application 10177977, Does medical cannabis reduce opioid analgesics in HIV+ and HIV- adults with pain? (5R01DA044171-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10177977. Licensed CC0.

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