# Overall NIDA Core "Center of Excellence" in Transcriptomics, Systems Genetics and the Addictome

> **NIH NIH P30** · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2021 · $744,955

## Abstract

Addiction is a highly complex disease with risk factors that include genetic variants and differences in
development, sex, and environment. The long term potential of precision medicine to improve drug treatment
and prevention depends on gaining a much better understanding how genetics, drugs, brain cells, and
neuronal circuitry interact to influence behavior. There are serious technical barriers that prevent researchers
and clinicians from incorporating more powerful computational and predictive methods in addiction research.
The purpose of the NIDA P30 Core Center of Excellence in Omics, Systems Genetics, and the Addictome
is to empower and train researchers supported by NIH, NIDA, NIAAA, and other federal and state institutions
to use more quantitative and testable ways to analyze genetic, epigenetic, and the environmental factors that
influence drug abuse risk and treatment. In the Transcriptome Informatics and Mechanisms research core we
assemble and upgrade hundreds of large genome (DNA) and transcriptome (RNA) datasets for experimental
rodent (rat) models of addiction. In the Systems Analytics and Modeling research core, we are using innovative
systems genetics methods (gene mapping) to understand the linkage between DNA differences, environmental
risks such as stress, and the differential risk of drug abuse and relapse. Our Pilot core is catalyzing new
collaborations among young investigator in the field of addiction research. In sum the Center is a national
resource for more reproducible research in addiction. We are centralizing, archiving, distributing, analyzing and
integrating high quality data, metadata, using open software systems in collaboration with many other teams of
researchers. Our goal is to help build toward an NIDA Addictome Portal that will include all genomic research
relevant to addiction research.

## Key facts

- **NIH application ID:** 10177978
- **Project number:** 5P30DA044223-05
- **Recipient organization:** UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- **Principal Investigator:** Laura Maren Saba
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $744,955
- **Award type:** 5
- **Project period:** 2017-08-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10177978

## Citation

> US National Institutes of Health, RePORTER application 10177978, Overall NIDA Core "Center of Excellence" in Transcriptomics, Systems Genetics and the Addictome (5P30DA044223-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10177978. Licensed CC0.

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