# ShEEP Request for Enabling 3D Nano-Printer Technology

> **NIH VA IS1** · SOUTHERN ARIZONA VA HEALTH CARE SYSTEM · 2021 · —

## Abstract

PROJECT SUMMARY/ABSTRACT
 The requested instrumentation is an advanced 3D printing system for biological applications that overcomes
much of the length-scale limitations of traditional additive manufacturing printing devices. The instrumentation
utilizes two tandem technologies of direct molecular printing and ultraviolet light energy transfer to develop
bioengineered devices that are uniform, highly controllable and have resolution and length-scales in the
nanometer to micrometer-range. The instrumentation is designed to produce controllable, molecular arrays to
investigate receptor-ligand, protein-protein, or enzyme-inhibitor interactions with specific applications to: 1)
tissue engineering, 2) cell-based studies that influence cellular differentiation and function, 3) drug discovery and
4) microbiology. The primary goal of the instrumentation is to fabricate novel bioengineered devices that consist
of arrays of peptides, glycoproteins or oligonucleotides; precisely defined microfluidic channels; and chemically
or geometrically tailored biofunctional chips to advance the research domains listed above that cover VA-funded
research at the Southern Arizona VA Health Care System (SAVAHCS). Additionally, the 3D nano-printing system
may be accessed by investigators at the academic affiliate, the University of Arizona, and other collaborators
throughout the region, which will expand the impact of the instrumentation and enhance research collaborations,
specifically between the two nearby medical centers and generally throughout the southwestern region.

## Key facts

- **NIH application ID:** 10179144
- **Project number:** 1IS1BX005549-01
- **Recipient organization:** SOUTHERN ARIZONA VA HEALTH CARE SYSTEM
- **Principal Investigator:** JASON A WERTHEIM
- **Activity code:** IS1 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2021
- **Award amount:** —
- **Award type:** 1
- **Project period:** 2020-10-01 → 2021-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10179144

## Citation

> US National Institutes of Health, RePORTER application 10179144, ShEEP Request for Enabling 3D Nano-Printer Technology (1IS1BX005549-01). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10179144. Licensed CC0.

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