# Core C: Clinical and Biostatistic Core

> **NIH NIH U19** · EMORY UNIVERSITY · 2021 · $375,823

## Abstract

The over-arching goal of this proposal is to analyze SARS-CoV-2 antibody seroconversion rates in health
care workers at the Emory University Hospital over the next year and to study adaptive immune responses
to SARS-CoV-2 infection during acute infection and at convalescence. These studies will draw on three
main sources of samples, either through an emerging infectious disease protocol at the Emory Vaccine
Center Hope Clinic, through a sero-surveillance study initiated at Emory, and previously collected PBMC
and serum samples from adult or elderly donors by Dr. Jorg Goronzy, respectively. We will develop and
employ a combination of antibody binding assays and viral neutralization assays to test the quantity and
quality of the infection-induced antibody responses. This information will also be used to identify optimal
donors for single-cell antibody expression cloning, as we have previously described. A recently
purchased 10x instrument in our BSL3 facility at the Emory Vaccine Center will allow for a detailed analysis
of the transcriptional profiles of innate and adaptive immune responses during acute SARS-CoV-2
infection. The proposed studies will provide key insight into the dynamics of this devastating disease
among health care workers at a major metropolitan hospital in Atlanta. These efforts will also generate key
serological tools, provide an understanding of the humoral immune response to SARS-CoV-2 infection,
and generate human monoclonal antibodies, with both diagnostic and therapeutic potential.

## Key facts

- **NIH application ID:** 10179296
- **Project number:** 5U19AI057266-18
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Srilatha Edupuganti
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $375,823
- **Award type:** 5
- **Project period:** 2003-09-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10179296

## Citation

> US National Institutes of Health, RePORTER application 10179296, Core C: Clinical and Biostatistic Core (5U19AI057266-18). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10179296. Licensed CC0.

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