# Field-Deployable Lab-on-a-Chip Nanosensing Platforms for Health and Environmental Monitoring

> **NIH NIH P42** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $369,472

## Abstract

ABSTRACT: PROJECT 2 
The proposed project describes a comprehensive research plan to develop and apply automated field- 
deployable lab-on-a-chip nanosensing platforms with high throughput, sensitivity and efficiency for multi- 
functional analysis of hazardous substances relevant to health and environmental monitoring in the Superfund 
Research Center (SRC). As extensive human activities pose increased environmental challenges worldwide, 
modern environmental monitoring and analytical technologies become particularly important to protect human 
health from adverse exposure to industrial pollutants, and to considerably improve public awareness. However, 
conventional laboratory-based analytical instruments are typically expensive and bulky, and require elaborate 
operational procedures conducted by dedicated personnel. The objective of this work is to deliver field- 
deployable multipurpose lab-on-a-chip technologies enabled by emerging microfluidics and nanosensing 
technologies for application in environmental monitoring and human health. Specifically, two innovative 
technological platforms to be investigated are: 1) a microfluidic print-to-analyze (MPA) system for high- 
throughput high-sensitivity biomolecular analysis (Aim I), and 2) a field-deployable ELISA-on-a-chip platform to 
incorporate quantitative nanosensing molecular assays (Aims II-IV), from which a 3D printable device can be 
customized and interfaced with mobile devices for health and environmental monitoring. Upon development, 
these technologies are expected to facilitate multiplexed, quantitative, automated processing and analysis of 
human biospecimens and environmental samples, with high sensitivity, quick turnover at low cost. Initial 
studies will involve testing these devices to detect pesticides and their degradation products, as an identified 
high concern for our community partner. More broadly, these platforms will be easily adaptable to commercial 
biorecognition molecules and detection of numerous Superfund priority chemicals. Overall, this research 
project directly advances the NIEHS mandate to develop analytical tools for the detection of hazardous 
chemicals and to apply them to environmental and human health monitoring applications.

## Key facts

- **NIH application ID:** 10179384
- **Project number:** 5P42ES004699-33
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Gang Sun
- **Activity code:** P42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $369,472
- **Award type:** 5
- **Project period:** 1997-04-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10179384

## Citation

> US National Institutes of Health, RePORTER application 10179384, Field-Deployable Lab-on-a-Chip Nanosensing Platforms for Health and Environmental Monitoring (5P42ES004699-33). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10179384. Licensed CC0.

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