# The critical role of bromodomain proteins TgBDP1 and TgBDP2 in regulating gene expression in the protozoan parasite Toxoplasma gondii

> **NIH NIH P20** · UNIVERSITY OF NEW HAMPSHIRE · 2021 · $314,192

## Abstract

The innate immune response to pathogens involves the expression and secretion of inflammatory 
cytokines that act to facilitate eradication of the infecting pathogen. The dysregulation of cytokine 
production (chronic inflammation) can have negative effects on the host. Therefore, a fundamental 
understanding of the molecular mechanisms regulating inflammation is essential for the development of 
therapeutic approaches for inflammatory disorders. We identify a novel role for the transcription factor 
GLI3 in regulating cytokine expression in response to TLR-TRIF signaling. GLI3 KO in monocytes induces 
a phenotype that indicates GLI3 associates with inflammatory pathways in response to TLR-TRIF 
stimulation. In this proposal, we will further elucidate the role of GLI3 in regulating cytokine expression in 
monocytes and explore the relevance of this regulation in inflammatory responses.

## Key facts

- **NIH application ID:** 10179421
- **Project number:** 5P20GM113131-05
- **Recipient organization:** UNIVERSITY OF NEW HAMPSHIRE
- **Principal Investigator:** Victoria Jeffers
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $314,192
- **Award type:** 5
- **Project period:** 2017-08-01 → 2023-08-15

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10179421

## Citation

> US National Institutes of Health, RePORTER application 10179421, The critical role of bromodomain proteins TgBDP1 and TgBDP2 in regulating gene expression in the protozoan parasite Toxoplasma gondii (5P20GM113131-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10179421. Licensed CC0.

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