# A multicity study of wintertime inversions and acute cardiorespiratory health events in the western U.S. > **NIH NIH R01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2021 · $561,664 ## Abstract ABSTRACT Identifying air pollution sources is critical for developing mitigation strategies to protect human health. Many cities in the western United States experience elevated short-term PM2.5, composed of heterogeneous PM2.5 mixtures that vary seasonally. PM2.5 is a mixture of primary PM2.5 (aerosols emitted directly from a source) and secondary PM2.5 (aerosols formed in the atmosphere from reactions involving primary pollutants, precursor emissions, and atmospheric processes). Although source apportionment models can be applied to trace pollutants back to their emission sources, all conventional source apportionment models share a common limitation: only the primary PM2.5 is apportioned. Meteorology plays a significant role in elevated air pollution concentrations during colder months in the western U.S. Under typical meteorological conditions, temperature decreases as altitude increases. During an inversion, this relationship is inverted – warm air is held above cooler air – causing ambient air pollutants, such as PM2.5, to be trapped near ground level. Several major historical air pollution events, including the 1952 London “Great Smog,” were caused by inversions. During colder months in the western U.S., it is common for over 80% of the total PM2.5 to be secondary PM2.5. To create effective regulations to protect human health in these cities, air quality managers must understand the origin of secondary PM2.5. Given the predominance of secondary PM2.5 during colder months, existing source apportionment models cannot reliably identify which source(s) should be prioritized for mitigation strategies. We propose to address this public health problem by developing an innovative air quality model that apportions both primary and secondary PM2.5, and to use the estimates from this model in a large 12-city epidemiologic study. We will develop a new data fusion method that combines air quality model results and speciated PM2.5 observations to create seasonal, location-specific source profiles for both primary and secondary PM2.5 species. These new source profiles will be used in a multi-year source apportionment model to estimate daily PM2.5 source concentrations during colder months for Boise, Salt Lake City, Provo, Ogden, Denver, Reno, Las Vegas, Sacramento, Fresno, Modesto, Bakersfield, and Visalia. Emergency department visit data from these cities will be used to estimate associations between the PM2.5 source concentration estimates and cardiorespiratory emergency visits. Our project directly addresses major limitations in existing source apportionment approaches by developing methods to apportion secondary PM2.5. Our multicity epidemiologic analyses will uniquely contribute to the literature by providing source-specific health associations that comprehensively account for both primary and secondary PM2.5 originating from a given source. We focus on the significant public health problem of PM2.5 in western U.S. cities prone to inversions and... ## Key facts - **NIH application ID:** 10180521 - **Project number:** 1R01ES032810-01 - **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH - **Principal Investigator:** Heather A Holmes - **Activity code:** R01 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2021 - **Award amount:** $561,664 - **Award type:** 1 - **Project period:** 2021-04-14 → 2026-01-31 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10180521 ## Citation > US National Institutes of Health, RePORTER application 10180521, A multicity study of wintertime inversions and acute cardiorespiratory health events in the western U.S. (1R01ES032810-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10180521. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*