PROJECT SUMMARY The overall goal of SHERC is to increase basic biomedical, clinical, and behavioral research at NAU to address health disparities among diverse populations of the Southwestern United States. In the first 5 years, we will increase research capacity in the areas of environmental and community health, building on a strong research base at NAU. Over time, SHERC will work closely with community partners to expand capacity to address health disparities in chronic and infectious diseases, as well as high-priority behavioral health conditions, as determined by community partners. SHERC consists of five cores that all interact synergistically. Each of the SHERC cores provides a clear opportunity for innovation individually; in combination, they demonstrate significant impact in innovation. The Administrative Core combines evidence-based organizational theory with a tested but novel use of a “continuous improvement” model of program assessment and feedback. The Research Infrastructure Core will focus on infrastructure improvement for the SHERC basic research, informatics, clinical, and community engaged science programs. In addition, it will take a leadership role in improving the interdisciplinary science efforts in biomedical, clinical, and community health science initiatives throughout NAU. The Investigator Development Core will support the development of early career investigators in basic biomedical, behavioral, and clinical sciences at NAU through two innovative programs: a Pilot Project Program (PPP) to support faculty and a Postdoctoral Scholar Program (PSP) to support and mentor postdoctoral researchers. The Community Engagement Core uses an innovative four- direction Framework for Inquiry and Action that will represent the shared and distinct determinants of health in Arizona. The five Research Projects include the following innovative studies: Pearson's research project will define and contrast S. aureus carriage and circulating genotypes with clinical genotypes and infection prevalence to better understand how social interactions impact transmission. Kellar and Propper seek to enhance current research on the relationship between environmental contaminants and clinical complications such as non-healing chronic wounds. The Varadaraj study will exploit a cellular adaptation in tumors, to determine whether altering fibrillogenesis in such states will switch premalignant cells to malignant cells and whether preinvasive cells would become invasive. Naren's study has the potential to improve and extend reovirus based cancer therapies. Fofonav's study may identify individuals with an oral microbiome that is more susceptible to early childhood caries (ECC) or individuals with particularly pathogenic strains of S. mutans and S. sobrinus.