# Telehealth Assessment of Syndromic Autism Risk in Infants

> **NIH NIH K23** · PURDUE UNIVERSITY · 2021 · $182,239

## Abstract

PROJECT SUMMARY / ABSTRACT
Despite affecting 1 in 68 United States children, the mechanisms and early course of autism spectrum disorder
(ASD) are largely unknown, delaying initiation of interventions known to alter the course of behavioral and neural
development. Current studies of ASD emergence largely focus on infant siblings of children with ASD (ASIBs)
who exhibit 20 times higher ASD risk than children without a family history. As a complement to this approach,
studying the emergence of ASD in high-risk neurogenetic syndromes informs: (1) the generalizability of behav-
ioral ASD “red flags” to non-ASIBs, given the majority of children with ASD do not have positive sibling histories,
and (2) genetic and biological pathways subserving ASD features, facilitating mechanistically-sensitive treat-
ments. However, syndromic ASD studies are rarely attempted in infants due to the high costs, travel demands,
and logistical challenges of assessing low-incidence groups. Furthermore, existing telehealth methods that could
circumvent these challenges are not compatible with experimental, laboratory-based methods (e.g. visual atten-
tion tasks, psychophysiology) sensitive to ASD risk. This Mentored Patient-Oriented Research Career Develop-
ment Award (K23) will prepare Dr. Tonnsen, a clinically trained psychologist with expertise in ASD emergence
in syndromic infants, to address these barriers by establishing a novel, telehealth-based assessment framework
for prodromal ASD surveillance. This project leverages the candidate’s current expertise in biobehavioral pre-
dictors of ASD through additional mentored training in (1) new ASD risk domains outside of her current expertise
(e.g. social communication, motor skills), (2) telehealth-based clinical research, (3) mechanisms and pathways
of syndromic ASD, (4) psychometrics and measurement, and (5) program management, academic writing, and
ethics. Primary mentors are experts in the measurement of developmental psychopathology (Don Lynam, Ph.D.),
syndromic ASD and telehealth (Leonard Abbeduto, Ph.D.), and social communication development in infants
(Amanda Seidl, Ph.D.). Additional training is provided by a national team of experts across both patient-oriented
(e.g. clinical profiles, treatment trials, healthcare engineering) and basic (e.g. genetics, mouse models) domains.
With the support of her mentorship team, Dr. Tonnsen will develop and validate a telehealth assessment battery
of prodromal ASD risk in local infants with syndromic intellectual disability (Aim 1). She will then remotely apply
the battery to a national longitudinal sample of infants with Angelman syndrome (50% ASD risk) and fragile X
syndrome (25-60% ASD risk; Aim 2) to generate preliminary data and hypotheses for a subsequent R01. The
proposed research is innovative because it represents a substantial departure from current methodological
frameworks and participant samples for prospective ASD studies, laying the foundation for higher-powered...

## Key facts

- **NIH application ID:** 10181077
- **Project number:** 5K23MH111955-05
- **Recipient organization:** PURDUE UNIVERSITY
- **Principal Investigator:** Bridgette Lynne Kelleher
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $182,239
- **Award type:** 5
- **Project period:** 2017-06-15 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10181077

## Citation

> US National Institutes of Health, RePORTER application 10181077, Telehealth Assessment of Syndromic Autism Risk in Infants (5K23MH111955-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10181077. Licensed CC0.

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