# Natural history study of x-linked Dystonia Parkinsonism

> **NIH NIH R21** · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $210,000

## Abstract

Project Summary
X-linked dystonia Parkinsonism (XDP) is a neurodegenerative disease that affects men
whose mothers originate from the island of Panay, Philippines. Due to the relatively
isolated region in which those with XDP live, and the rarity of the disease itself, limited
data regarding the natural history is currently available. The goal of this application is to
solidify an already established collaboration for a natural history study and the collection
of DNA and other biological fluids. Natural history studies are important for understanding
the etiology, range of manifestations and progression of a rare disease. Biospecimens are
crucial to understand the underlying pathology at both the molecular and cellular level. In
addition, investigators in the Philippines will undergo training in clinical research
methodology in the United States. The training will improve their ability to conduct
independent research on XDP in the Philippines.

## Key facts

- **NIH application ID:** 10181089
- **Project number:** 5R21NS118541-02
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** NUTAN SHARMA
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $210,000
- **Award type:** 5
- **Project period:** 2020-06-15 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10181089

## Citation

> US National Institutes of Health, RePORTER application 10181089, Natural history study of x-linked Dystonia Parkinsonism (5R21NS118541-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10181089. Licensed CC0.

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