# Applied Research

> **NIH NIH P40** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 · $91,236

## Abstract

PROJECT SUMMARY. The demonstration in the late `80s and early `90s that specific strains of herpes and
rabies virus are transported transneuronally exclusively at synapses in a time- and direction-dependent fashion
opened up a new era in experimental neuroanatomy. Virus transneuronal transport is uniquely able to reveal
the cellular composition of multi-synaptic circuits. As a consequence, this technique is providing fundamental
new insights into the functional architecture of sensory, motor, cognitive and affective circuits in the central
nervous system. The Center for Neuroanatomy with Neurotropic Viruses (CNNV) was created in 2004 to
provide the neuroscience community with access to the highly specialized reagents, training and facilities that
are necessary to use neurotropic viruses as transneuronal tracers.
We document in this application that the CNNV has become an essential national and international resource for
an important segment of the neuroscience community. Users of the Center are funded by 15 different institutes
of the NIH, by NSF and by private foundations and international research organizations. The Center has
established a strong history of providing well-characterized reagents, training and guidance in the use of the
method, and specialized biohazard facilities for performing experiments using neurotropic viruses. The Center
has served as an essential technical and intellectual resource for those interested in using this novel method.
The goal of the Resource Component of this competitive renewal is to continue these essential functions of the
Center.

## Key facts

- **NIH application ID:** 10181092
- **Project number:** 5P40OD010996-17
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Peter Strick
- **Activity code:** P40 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $91,236
- **Award type:** 5
- **Project period:** 2003-07-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10181092

## Citation

> US National Institutes of Health, RePORTER application 10181092, Applied Research (5P40OD010996-17). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10181092. Licensed CC0.

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