# BioBehavioral Assessment (BBA)

> **NIH NIH P51** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $12,683,326

## Abstract

PRIMATE SERVICES: BIOBEHAVIORAL ASSESSMENT
ABSTRACT
Our unique developmental and biobehavioral makeup affects our risk for disease and the effectiveness of
medical intervention, a key concept in precision medicine. It is becoming increasingly clear that biomedical
models of disease must account for individual variation to achieve peak translatability with human health
research. The BioBehavioral Assessment (BBA) Program at the California National Primate Research
Center (CNPRC), launched in 2001, has quantified measures of biobehavioral organization (i.e.,
temperament, physiological reactivity, genetics) in more than 5000 infant rhesus monkeys to date. BBA has
provided the basis for more than 70 publications and has contributed important discoveries on the
developmental roots of health and disease (e.g., asthma, autism, depression, and diarrhea). BBA has been
identified as a keystone CNPRC research resource by our National Scientific Advisory Board and in base
grant reviews. The goals of this program have been threefold: 1) to comprehensively inventory individual
macaque biobehavioral organization and relate this information to health outcomes; 2) to make data
available as a resource for scientific inquiry (e.g., for subject selection); and 3) to contribute to the
knowledge and improvement of the nonhuman primate resource at our own center, and through our
published studies, provide important information to management staff at other primate facilities in the United
States as well. In this revised P51 application to embed BBA as a CNPRC animal resource, we propose to
optimize this exceptional program with a new vision to propel the BBA resource into the next decade of NHP
research. This four-tiered vision includes: 1.) Developing new constructs from historical BBA data to predict
health and disease, 2.) stimulating a longitudinal health span approach in CNPRC research, by formally
linking BBA with our NIA geriatric research program 3.) increasing user ship of the resource by offering
consulting and custom testing options for PIs, and 4.) making BBA data universally accessible by
developing and beta testing an interactive educational and data sharing website to be completed in three
phases, made public in 2020 and completed by 2022. It is anticipated that new BBA research directions and
accessibility will yield a large leap forward in scientific discovery and public understanding of biobehavioral
organization in NHP development.

## Key facts

- **NIH application ID:** 10181095
- **Project number:** 5P51OD011107-60
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** JOHN P CAPITANIO
- **Activity code:** P51 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $12,683,326
- **Award type:** 5
- **Project period:** 1997-05-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10181095

## Citation

> US National Institutes of Health, RePORTER application 10181095, BioBehavioral Assessment (BBA) (5P51OD011107-60). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10181095. Licensed CC0.

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