# Chemistry & DMPK Core

> **NIH NIH P30** · UNIVERSITY OF MISSISSIPPI · 2021 · $240,930

## Abstract

PROJECT SUMMARY/ABSTRACT
The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) at The University of
Mississippi School of Pharmacy (UM), initiated ten years ago through a COBRE grant, has developed a
multidisciplinary team committed to evaluating the effects of natural products on the central nervous system
(CNS). The Center now has the potential to develop and sustain an innovative and independently funded
research center focused on treating disorders associated with the nervous system. Medicinal chemistry, drug
metabolism, and pharmacokinetics (DMPK) are vital components of the iterative cycle of drug discovery, both
embedded in hit-to-lead and lead optimization stages. The Chemistry/DMPK Research Core of the COBRE
CORE-NPN program represents a shared core facility with the goal of serving biomedical investigators/users
with consultation and specialized services and training in synthetic medicinal chemistry and DMPK as broadly
defined within the NPN program. This Core is positioned to become a leader in synthesis, analysis, and early-
stage DMPK evaluation of natural product and synthetic small-molecule drug discovery and development
campaigns by accomplishing the following Specific Aims: (1) To strengthen the Chemistry/DMPK Research
Core by providing users with enhanced services, access, and training in state-of-the-art instrumentation,
specialized techniques, and scientific expertise; (2): To advance an infrastructure of developmental services to
facilitate COBRE CORE-NPN research; (3): To accelerate a long-term plan for sustainability of the Core through
expansion of the user base, research partnerships and collaborations, integration of a fee-for-service structure,
institutional support, and adaptation to changes by monitoring the needs of the users. These aims will facilitate
the transition of the Chemistry-DMPK Core into a fully self-sustained facility providing specialized research
services and training opportunities essential in supporting investigators and bridging the drug discovery gap by
providing users with consultation, training, and services in medicinal chemistry/DMPK, helping to alleviate the
bottleneck associated with compound acquisition and evaluation.

## Key facts

- **NIH application ID:** 10182735
- **Project number:** 5P30GM122733-04
- **Recipient organization:** UNIVERSITY OF MISSISSIPPI
- **Principal Investigator:** John M Rimoldi
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $240,930
- **Award type:** 5
- **Project period:** 2018-08-15 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10182735

## Citation

> US National Institutes of Health, RePORTER application 10182735, Chemistry & DMPK Core (5P30GM122733-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10182735. Licensed CC0.

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