# Structure and mechanism of mammalian ferroportin

> **NIH NIH R01** · BAYLOR COLLEGE OF MEDICINE · 2021 · $400,000

## Abstract

Project Summary:
Ferroportin is the only iron exporter in humans. Mutations in ferroportin cause
hemochromatosis. Ferrorpotin is regulated by a peptide hormone hepcidin, which is
produced in the liver and inhibits the activity of ferrorportin by inducing endocytosis and
by direct inhibition of ferroportin activity. The FPN-hepcidin axis is a potential therapeutic
target for normalizing iron homeostasis in hemochromatosis. However, very little is
known about how ferroportin recognizes and transport iron and how it interacts with
hepcidin. In this study, I will combine structural and functional analyses to understand
the mechanism of iron transport and inhibition in ferroportin at the atomic resolution.

## Key facts

- **NIH application ID:** 10183365
- **Project number:** 1R01HL157473-01
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Yaping Pan
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $400,000
- **Award type:** 1
- **Project period:** 2021-05-01 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10183365

## Citation

> US National Institutes of Health, RePORTER application 10183365, Structure and mechanism of mammalian ferroportin (1R01HL157473-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10183365. Licensed CC0.

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