# DR. EPS: Drug Repurposing for Extended Patient Survival

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $1

## Abstract

Project Summary
Human cancers are complex diseases that present vast heterogeneity, leading to widely different survival
outcomes. Thus actionable and robust predictive models for cancer prognosis are much needed for more
personalized treatment and disease management. However, There has been severely lacking of
therapeutically actionable computational methods, which explicitly model patient survival difference as the
objective while integrating multi-dimension high-throughput genomics data. To solve this issue, we propose a
novel actionable framework for caner drug repurposing, called DR. EPS (Drug Repurposing for Extended
Patient Survival). Towards this goal, we will develop the following strategies: (1) Constructing and validating a
new class of hybrid-learning based, multi-omics prognosis modeling approach, using seven diverse liver
cancer population cohorts. (2) Developing and experimentally validating an actionable computational drug-
repurposing framework to improve the survival of high-risk liver cancer patients, using big sets of
pharmacogenomics and pharmacogenetics data. (3) Building a user-friendly webtool that accelerates such
bench-to-bed transition for liver cancer treatment. We expect that this project will be groundbreaking in many
aspects, including building new prognostic models on multi-omics data sets, identifying new repurposed drugs
to extend high-risk liver cancer patient life-spans, and providing a first-hand drug reposition resource for liver
cancer therapeutics research community.

## Key facts

- **NIH application ID:** 10186808
- **Project number:** 5R01LM012907-03
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Lana X Garmire
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1
- **Award type:** 5
- **Project period:** 2019-09-21 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10186808

## Citation

> US National Institutes of Health, RePORTER application 10186808, DR. EPS: Drug Repurposing for Extended Patient Survival (5R01LM012907-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10186808. Licensed CC0.

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