# Integrative Data Analysis of Coping Power: Effects on Adolescent Suicidality

> **NIH NIH R01** · RESEARCH TRIANGLE INSTITUTE · 2021 · $496,927

## Abstract

PROJECT SUMMARY/ABSTRACT
 Suicide is the second leading cause of death among individuals aged 10-34 in the US, with 17% of high
school-aged youth seriously considering a suicide attempt and 8% attempting suicide. There is emerging
evidence to suggest that preventive interventions that do not explicitly target suicide have “crossover” effects
on suicidality. However, the majority of interventions that have been examined for their impact on suicide target
internalizing behaviors, which may miss a significant subset of boys, whose risk for suicidality is primarily
transmitted through externalizing; this concern is echoed by calls in the recent suicide prevention literature for
addressing the dearth of literature on suicide crossover effects from externalizing-focused interventions.
 The Coping Power (CP) program is an empirically supported, child- and family-focused preventive
intervention that focuses on reducing externalizing more broadly among youth who exhibit early aggression,
which makes it ideally suited to addressing the above-mentioned gaps in targeting externalizing pathways to
suicidality. The proposed study will combine data from 10 randomized controlled trials (RCTs) of CP (total
individual-level N = 3,201; total school-level N = 188) and utilize three measurement and data analysis
frameworks that have emerged across multiple independent disciplines: integrative data analysis (IDA), meta-
analysis of individual patient data (MIPD), and propensity score weighting (PSW). Using these frameworks, we
propose the following aims:
Aim 1: Estimate scale scores for key constructs while accounting for differential item functioning
across studies, time, populations, and reporters.
Aim 2: Assess comparative effect sizes for multiple forms of Coping Power (CP) using IDA-estimated
scale scores for CP mechanisms of action, externalizing, internalizing, and suicidality.
Aim 3: Test for potential mediators of CP effects on risk for suicidality as transmitted through CP's
mechanisms of action (MoAs) and/or intermediate endpoints.
Aim 4: Explore individual-, school- and study-level moderators of CP's effects on MoAs, intermediate
endpoints, and risk for suicidality.
 If successful, the proposed study will (1) be one of the first to apply a symptom weighting framework (e.g.,
MNLFA, item response theory) for measuring suicidality, while accounting for measurement bias across
multiple factors (e.g., time, development, demographic variables, reporters), (2) provide initial evidence for
preventive effects on suicidality through gender-specific pathways (externalizing for boys, internalizing for
girls), (3) illustrate evidence that CP's direct and/or indirect impact on reductions in suicidality is greater among
youth who are at higher initial risk, and (4) identify the optimal conditions for CP delivery (e.g., group,
individual, internet) for different youth characteristics (which could not be examined in any single RCT of CP).

## Key facts

- **NIH application ID:** 10186829
- **Project number:** 5R01MH124438-02
- **Recipient organization:** RESEARCH TRIANGLE INSTITUTE
- **Principal Investigator:** JOHN E LOCHMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $496,927
- **Award type:** 5
- **Project period:** 2020-07-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10186829

## Citation

> US National Institutes of Health, RePORTER application 10186829, Integrative Data Analysis of Coping Power: Effects on Adolescent Suicidality (5R01MH124438-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10186829. Licensed CC0.

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