# Implantable Bio-Artificial Pancreas (iBAP)

> **NIH NIH U01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $806,915

## Abstract

PROJECT SUMMARY/ABSTRACT
As of May 25th, 2020, there were over 5.5 million confirmed cases of COVID-19 worldwide and around 1.7
million in the US, where almost 100,000 deaths have occurred. Acute Respiratory Distress Syndrome (ARDS)
presents secondary to COVID-19 and is primarily treated by mechanical ventilation. Of all hospitalized COVID-
19 patients, around 20% will be intubated and mechanically ventilated. Unfortunately, ARDS patients are
especially susceptible to ventilator induced lung injury (VILI) and as many as 80% of intubated COVID-19
patients have died. In contrast, ECMO bypasses the lungs, thereby avoiding VILI, and the patient’s blood is
directly oxygenated using an extracorporeal circuit containing a gas-permeable membrane. While ECMO has
shown increased survival relative to mechanical ventilation, the complexity of the ECMO procedure, associated
bleeding and clotting risks, and labor intensiveness has restricted its use. We propose to develop a new
oxygenator membrane constructed from silicon nanopore membranes (SNM). The enhanced biocompatibility
and increased gas flux of the SNM will enable the Silicon Membrane Oxygenator (SiMOx) - a compact and
potentially anticoagulation-free ECMO system. The SiMOx will establish a new paradigm of “set it and forget it”
blood oxygenation that is characterized by decreased operational complexity, diminished bleeding/clotting
risks, and reduced personnel needs.

## Key facts

- **NIH application ID:** 10186950
- **Project number:** 3U01EB025136-03S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** SHUVO ROY
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $806,915
- **Award type:** 3
- **Project period:** 2017-09-26 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10186950

## Citation

> US National Institutes of Health, RePORTER application 10186950, Implantable Bio-Artificial Pancreas (iBAP) (3U01EB025136-03S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10186950. Licensed CC0.

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