# Endothelial progenitor cells and neurovascular injury in the aging brain

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA-IRVINE · 2021 · $690,060

## Abstract

Project Summary
The proposed study will investigate the role of endothelial progenitor cells in neurovascular dysfunction and
cognitive decline among older adults with low levels of traditional vascular risk and normal baseline cognitive
function. Specifically, we will study whether changes in endothelial progenitor cell proliferation and senescence
are predictive of cognitive decline, vascular brain lesions and structural and functional brain connectivity. We will
also study secretory factors from endothelial progenitor cell cultures to better understand how progenitor cell
function relates to neurovascular dysfunction, brain injury and cognitive decline.

## Key facts

- **NIH application ID:** 10187482
- **Project number:** 5R01AG064228-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** Daniel A Nation
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $690,060
- **Award type:** 5
- **Project period:** 2019-09-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10187482

## Citation

> US National Institutes of Health, RePORTER application 10187482, Endothelial progenitor cells and neurovascular injury in the aging brain (5R01AG064228-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10187482. Licensed CC0.

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