# Genetics Core

> **NIH NIH P30** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2021 · $169,068

## Abstract

GENETICS CORE PROJECT SUMMARY/ABSTRACT
This new application will build on our work of the two previous funding cycles in which we established the Human
Genetics Core (HGC) as an essential part of the Columbia ADRC. The HGC provides a centralized resource for
the organization and analysis of genetic data within the ADRC and projects affiliated with the ADRC at Columbia
University by providing the full physical and intellectual infrastructure needed to coordinate genetic research
efforts and provide a platform for investigators to create a better understanding of genotype-phenotype
relationships for dementia and related endophenotypes.
Specifically, the HGC will: (1) provide a genetic material repository to process, extract, store and distribute
genetic material from patients and controls, and track the collection and usage of genetic material; (2) provide
a genetic database for storage, handling, preparation and distribution of genomic data from ADRC subjects
and large-scale datasets available to the ADRC; (3) provide a high-end cluster environment and analytical
support in statistical genetics and bioinformatics to facilitate genomic data analysis; (4) provide genetic
counseling to patients and their families participating in the ADRC and ADRC affiliated studies; and (5) extend
the large-scale genomic data available on this ADRC sample (ie. GWAS, WGS/WES, eQTL maps), and
comprehensively characterize subjects for genetic variation in the amyloid, tau, immune response, cholesterol
and endosomal trafficking pathways. In line with our vision for precision medicine, this characterization will move
us forward to i) provide investigators with a backbone for more targeted research informed by genetic
background, ii) disentangle potential pathophysiologic heterogeneity in this cohort, and iii) explore a variety of
critical questions addressing the Thematic Aim by integration with the extensive translational data generated by
the Neuropathology, Biomarker and Neuroimmunology Cores.

## Key facts

- **NIH application ID:** 10187491
- **Project number:** 5P30AG066462-02
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Christiane Reitz
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $169,068
- **Award type:** 5
- **Project period:** 2020-06-15 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10187491

## Citation

> US National Institutes of Health, RePORTER application 10187491, Genetics Core (5P30AG066462-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10187491. Licensed CC0.

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