# Implementation of Inpatient Postpartum Human Papillomavirus Immunization

> **NIH NIH K07** · YALE UNIVERSITY · 2021 · $165,013

## Abstract

Project Summary / Abstract
 Dr. Sheth is an obstetrician and gynecologist whose long-term goal is to optimize the implementation of
evidence-based recommendations for prevention of gynecologic cancers. The proposed training and mentored
research experience will enable her to achieve her short-term goals of developing expertise in conducting
dissemination and implementation (D&I) research on human papillomavirus (HPV) vaccine and of using
qualitative methods and medical informatics as research tools. Dr. Sheth has assembled an expert and
committed team of mentors and advisors to help her. Dr. Linda Niccolai (primary mentor) is a recognized leader
in HPV vaccine research and qualitative methods and Dr. Steven Bernstein (co-mentor) is an expert in D&I
research for cancer prevention. Dr. Sheth will complete a certificate program in D&I science through UCSF, take
advanced courses at Yale on qualitative methods, clinical informatics and the design and conduct of clinical
trials, and complete a course on the design of health IT tools through Oregon Health and Science University.
 Each year in the U.S., HPV causes approximately 330,000 cases of precancerous cervical dysplasia,
and 12,000 cases of cervical cancer. Since 2006, FDA-approved HPV vaccines have been available.
Immunization is recommended routinely for all 11-12 year olds, and as catch-up immunization through age 26
years. However, uptake of HPV vaccine in the U.S. is poor: overall, only 43% of adolescents are fully immunized.
Sustained efforts for catch-up immunization are critical to address missed opportunities to protect women against
HPV-associated diseases. Even among women who have been sexually active before immunization, a
substantial burden of disease can be prevented, especially since the current vaccine protects against 9 different
HPV types responsible for >80% of cervical cancers. One strategy to improve HPV immunization rates is to
vaccinate postpartum women during their hospitalization when there is easy access to patients. This would also
reduce the number of visits needed to complete the multi-dose series. Several other vaccines (Tdap, influenza,
MMR) have been integrated into postpartum hospital care for catch-up immunization, but not so the HPV vaccine.
 We aim to promote integration of inpatient postpartum HPV immunization (IPP-HPV) into routine care by
developing an electronic medical record (EMR)-based tool modeled on current practices used for other vaccines
administered during inpatient postpartum care and on stakeholder preferences. We will evaluate the feasibility
of using the EMR-based tool as an implementation strategy for achieving high fidelity and sustainability of IPP-
HPV immunization. This study will help inform development of an implementation toolkit for IPP-HPV
immunization to use in a subsequent full-scale hybrid implementation and effectiveness trial. Upon completion
of this award, Dr. Sheth will have expertise in D&I science research methods. She will ha...

## Key facts

- **NIH application ID:** 10187528
- **Project number:** 5K07CA230234-04
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Sangini S. Sheth
- **Activity code:** K07 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $165,013
- **Award type:** 5
- **Project period:** 2018-07-11 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10187528

## Citation

> US National Institutes of Health, RePORTER application 10187528, Implementation of Inpatient Postpartum Human Papillomavirus Immunization (5K07CA230234-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10187528. Licensed CC0.

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