# Core B-Clinical Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA-IRVINE · 2021 · $739,329

## Abstract

Core B: Clinical Core 
Project Summary/Abstract 
The UCI ADRC Clinical Core enrolls, characterizes and follows a cohort of individuals who are cognitively 
unimpaired, cognitively impaired, or demented, each of whom complete the Uniform Data Set (UDS) consisting 
of physical and neurological exams and a battery of neurocognitive assessments. In addition to this UDS, 
participants and their study partners complete questionnaires and assessments unique to our ADRC, and 
voluntarily contribute a variety of tissue and biomarker assessments, including genetic analyses, volumetric 
imaging, cerebrospinal fluid analyses, and donation of fibroblasts for the generation of induced pluripotent stem 
cells (iPSC). Overall, 292 of our current 330 active participants have donated fibroblasts or peripheral blood 
mononuclear cells (PBMCs), which have been used to generate 192 iPSC lines by our iPSC Core. Most 
participants agree to brain donation at autopsy and we have a high rate of successful completion of autopsy 
confirmation at death. Our UDS cohort currently includes 330 active participants. Among this cohort, 60% are 
female and one third are non-White race or Hispanic ethnicity. Nineteen percent are demented, 18% meet 
criteria for Mild Cognitive Impairment (MCI), and a majority (60%) do not meet diagnostic criteria for MCI or 
dementia. Our overall retention rates are very high and above the median for the ADRC system. Most UDS 
participants have been enrolled in externally funded ancillary studies, ranging from telephone interview studies 
to neuroimaging biomarker research. To support the increasing needs of ADRC investigators, including novel 
studies of molecular and vascular biomarkers, we will grow this UDS cohort to a steady state n=400, with an 
emphasis on enrolling individuals who enable novel studies in support of the UCI ADRC theme “to identify, 
quantify, and validate factors that influence the risk of AD across the lifespan.”!

## Key facts

- **NIH application ID:** 10188382
- **Project number:** 5P30AG066519-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** David Sultzer
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $739,329
- **Award type:** 5
- **Project period:** 2020-06-15 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10188382

## Citation

> US National Institutes of Health, RePORTER application 10188382, Core B-Clinical Core (5P30AG066519-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10188382. Licensed CC0.

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