# Innovative, non-invasive, battery-less, disposable cardiac biosensor for hemodynamic monitoring

> **NIH NIH R43** · AVENTUSOFT, LLC · 2021 · $225,000

## Abstract

7. PROJECT SUMMARY/ABSTRACT
This SBIR Phase I project will design and develop an innovative, miniature, battery-less, disposable cardiac
biosensor, to provide easy home assessment of heart and lung function. The biosensor will deliver comparable
hemodynamic measurements to the gold standard assessments. Economic impetus has led to early discharge
of complex and elderly patients with cardiovascular disease. Older adults discharged from hospitals following
diagnoses of congestive heart failure exacerbation, myocardial infarction, coronary artery bypass grafting
surgery or other high-risk cardiac procedures are at higher risk for re-hospitalizations and increased mortality
resulting from gaps in care following hospital discharge. The assessment solutions available for patient
monitoring at home, namely, blood pressure, weight, electrocardiograms, have not demonstrated reduction in
readmission for any reason or death of any causes after discharge. Invasive implant devices, such as
CardioMEMS, have demonstrated that hemodynamic measurements allow more effective management leading
to fewer hospitalizations and lower deaths. Thus, aging adults are in need of reliable, robust, safe (non-invasive),
and simple technologies that can provide hemodynamic assessment post hospitalization. There is need for
meaningful interventions through a phone consultation or outpatient primary care visits that reduce re-admissions
and mortality. Using this SBIRs technology, it will be possible for a patient to have access to gold standard
hemodynamic measurements, through an integrated, wearable, battery-less, cardiac biosensor. The biosensor’s
data can be read with a smart phone using secure near field communication, enabling patients and their health
care providers to have easy access to their hemodynamic measurements via a smartphone application. Early
objective measurements of hemodynamic changes will lead to early and prompt outpatient interventions. This
will improve the quality of life for individuals with chronic cardiovascular conditions enabling them to remain at
home longer. We have a multidisciplinary team of scientists and practice stakeholders who will work together to
develop and test the conceptual model that will be applicable across diverse patient populations. The overall
goal of this project it to demonstrate that new technology can meaningfully accommodate the needs of older
adults and address their unique problems and challenges. For the first time there will be a biosensor that truly
addresses the market need of an un-obstructive, non-invasive, accurate, absolute and actionable system for
post-discharge use at home. This will facilitate close self-monitoring and outpatient monitoring of our most
vulnerable patients, while maintaining close supervision by the health care teams. This battery-less, disposable
biosensor technology for providing in-depth hemodynamics has additional far reaching benefits. Such a device
does not exist today thus opening up n...

## Key facts

- **NIH application ID:** 10188673
- **Project number:** 1R43EB029884-01A1
- **Recipient organization:** AVENTUSOFT, LLC
- **Principal Investigator:** Kaustubh Kale
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $225,000
- **Award type:** 1
- **Project period:** 2021-09-20 → 2022-03-19

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10188673

## Citation

> US National Institutes of Health, RePORTER application 10188673, Innovative, non-invasive, battery-less, disposable cardiac biosensor for hemodynamic monitoring (1R43EB029884-01A1). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/10188673. Licensed CC0.

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