# Neural Mechanism for Successful Memory Access in the Cortico-Hippocampal Networks

> **NIH NIH R01** · UT SOUTHWESTERN MEDICAL CENTER · 2021 · $409,479

## Abstract

PROJECT SUMMARY
Successful memory retrieval is one of the most important functions in our brain. Numerous studies have shown
that hippocampal-entorhinal (HPC-EC) circuits play crucial roles in encoding and retrieval of specific episodic
memories. Many human patients who suffer from Alzheimer's disease, dementia and the broad spectrum of
psychosis, including schizophrenia, show various ranges of memory deficits along with the HPC-EC damage.
However, little is known about how specific memories are accessed and formed into meaningful memories to
accomplish given tasks, especially at the systems level. This proposal focuses on the neural dynamics for
successful memory access and retrieval during episodic working memory tasks to elucidate the neural circuit
mechanism in the hippocampal-cortical (HPC-CTX) network. My long-term goal is to elucidate neural dynamics
during psychotic states and to establish novel early-stage diagnostic measurements / analyses in human patients
that are hinted at by in vivo recordings in animal models. I have previously demonstrated two forms of memory
access in the HPC-EC circuits that are crucial during episodic memory tasks. The first form is called `gamma
phase synchrony', which was observed during the running period of a spatial working memory task when the
animal was about to make turns at the junction point of a T-maze. The second form is called an `extended
interregional ripple burst', a memory replay event that is made of alternating chains of burst activities within HPC-
EC network during quiet awake or stopping periods on a large running maze. These two forms of memory access
turned out to be crucial for subsequent spatial working memory behavior. However, the circuit mechanism or
memory contents during these neural activities under different behavioral states are still unknown. Revealing
such memory contents during the memory access period will be crucial to understanding of how exactly our
memory system works. We hypothesize that (i) the content of burst activities between HPC and EC index each
other to retrieve longer episodes as an inter-regional communication during the off-line state and then (ii) the
previously potentiated or activated group of neurons gets briefly activated in gamma phase synchrony during the
active state to successfully execute the memory process. We will test three hypotheses in this proposal by
combining transgenic mouse technology, circuit specific optogenetics, large-scale in vivo electrophysiology, and
a spatial working memory task in mice. The first two specific aims will focus on neural content decoding during
two forms of memory access and the third specific aim will investigate whether the two distinct forms of memory
process have a causal relationship on the successful accession of memory in the HPC-EC network.

## Key facts

- **NIH application ID:** 10189701
- **Project number:** 5R01MH120135-02
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** Jun Yamamoto
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $409,479
- **Award type:** 5
- **Project period:** 2020-06-15 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10189701

## Citation

> US National Institutes of Health, RePORTER application 10189701, Neural Mechanism for Successful Memory Access in the Cortico-Hippocampal Networks (5R01MH120135-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10189701. Licensed CC0.

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