PROJECT SUMMARY The Stanford Institute for Immunity, Transplantation, and Infection (ITI) has a robust track record of Administrative Core success within NIH-sponsored projects in regard to leadership and coordination of center activities, management of finances and resources, and facilitation of intra-center collaboration and scientific support. The success of the proposed center here will rely upon the success of its Administrative Core. Dr. Mark Davis, who has extensive experience managing large consortia with numerous projects, cores, and investigators, will be Core Lead of the Administrative Core in addition to his role as center PD/PI. He will share his primary responsibilities in this role with Dr. Shai Shen-Orr, and they will be assisted by Drs. Kari Nadeau and Holden Maecker. In their capacities as project and core leaders, they will be responsible for the overall organization, management, decision-making, and periodic evaluations within this center. In addition, they will oversee resource allocation, protection of intellectual property in conjunction with Stanford’s Office of Technology Licensing and the Technion’s T3 Commercial Unit, and the involvement of other institutional resources. Dr. Robert M. DiFazio, director of ITI’s Office of Strategy and Research Development, will commit the resources of his office along with Ms. Michele King to monitor overall progress, provide support to the administrative leadership team, and coordinate center activities and collaboration. They will be joined by Dr. Molly Miranda, who will oversee data sharing and upload of data to ImmPort.