# Surgery / Physiology Core

> **NIH NIH P01** · YALE UNIVERSITY · 2021 · $103,299

## Abstract

Abstract/Summary: Core C will continue to provide key animal models necessary for the studies of ERK 
signaling, miR 17-19 cluster biology, and matrix and mechanotransduction in arteriogenesis, and to facilitate 
evaluation and validation of discovery research carried out in the PPG projects. To this end, the Core has 
established 64 types of surgical animal models of human diseases. To meet the evolving needs of the 
program, we are introducing six mouse models including mouse hindlimb ischemia, stroke, Matrigel plug 
assay, skin wound healing, partial carotid ligation and cornea pocket assay. The Core is supported by 3 micro- 
surgeons with extensive microsurgery techniques experience and 2 technologists with experiences in animal 
care and handling under the direction of Dr. Zhang. These standardized efforts will result in facilitating the 
translation of ideas from the bench to mice, and ultimately to humans.

## Key facts

- **NIH application ID:** 10192385
- **Project number:** 5P01HL107205-09
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Jiasheng Zhang
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $103,299
- **Award type:** 5
- **Project period:** 2012-02-10 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10192385

## Citation

> US National Institutes of Health, RePORTER application 10192385, Surgery / Physiology Core (5P01HL107205-09). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10192385. Licensed CC0.

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