# Engineering Core C

> **NIH NIH P01** · UNIVERSITY OF WASHINGTON · 2021 · $203,415

## Abstract

PROJECT SUMMARY/ABSTRACT - Engineering Core (Core C)
 The Program will include an Engineering Core (Core C) co-led by Michael R. Bailey, Ph.D. and R. Lee
Thompson Ph.D. and housed in the Applied Physics Laboratory (APL) Transducer Array Fabrication Laboratory.
There is no off-the-shelf hardware to perform ultrasonic propulsion (UP) or burst wave lithotripsy (BWL). This
instrumentation is all custom built and requires specific expertise to create driving electronics and transducers
capable of safely and reliably generating the required outputs. These transducers produce outputs different from
typical high intensity focused ultrasound (HIFU) transducers and shock wave lithotripters and require specific
drive electronics to produce appropriate pulse types. Companies who develop traditional HIFU devices and
lithotripters have little or no experience with the design constraints of UP or BWL devices. No single commercially
available system or transducer can produce the large range of outputs desired for the parametric investigation
performed in Project 2, so several similar transducers must be made and calibrated. Core C is one of a handful
of facilities internationally with expertise and experience in fabricating imaging and therapy ultrasound systems
for industry and research, and thus, is unique in its ability to support this Program Project Grant.
 Core C will provide design, fabrication, and characterization support for the ultrasound transducers and
control/power electronics to be used by our research teams. The overall goal of Core C is to ensure that all
experiments are conducted with appropriate, calibrated, and accurate instrumentation. To accomplish that goal,
Core C has three specific aims. Aim 1 is to produce and maintain identical hardware systems across for all three
Projects. This work ensures that the Projects have the correct tools to perform their studies. Aim 2 is to certify
and maintain calibration of the UP and BWL hardware for all three Projects. This work establishes a quality
control framework acceptable to FDA for rigorous and reproducible results. Aim 3 is to engineer new hardware
to produce desired outputs and configurations needed for specific applications by each of the three Projects. As
research progresses, we expect to determine specific outputs or combinations of outputs that will enhance stone
specific (S-mode) ultrasound imaging, BWL, and UP applications. These enhancements may impose new
requirements on the range of outputs needed from a transducer or electronics. As such, in order to accomplish
the proposed Project Aims, Core C will design and fabricate new transducers or electronics, and perform
firmware and software coding of the outputs, and synchronization across outputs to meet the project
requirements.

## Key facts

- **NIH application ID:** 10192510
- **Project number:** 5P01DK043881-27
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** MICHAEL R BAILEY
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $203,415
- **Award type:** 5
- **Project period:** 1997-03-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10192510

## Citation

> US National Institutes of Health, RePORTER application 10192510, Engineering Core C (5P01DK043881-27). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10192510. Licensed CC0.

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